Evidence map›Paper›PMID 34198070›Full record

ArticleRedox biology2021

Reduced exploratory behavior in neuronal nucleoredoxin knockout mice.

Bao Ngoc Tran, Lucie Valek, Annett Wilken-Schmitz, Dominik Christian Fuhrmann, Dimitry Namgaladze, Ilka Wittig, Irmgard Tegeder

Abstract read
In one paragraph

Article in Redox biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bao Ngoc TranInstitute of Clinical Pharmacology, Goethe-University, Medical Faculty, Frankfurt, Germany.
Lucie ValekInstitute of Clinical Pharmacology, Goethe-University, Medical Faculty, Frankfurt, Germany.
Annett Wilken-SchmitzInstitute of Clinical Pharmacology, Goethe-University, Medical Faculty, Frankfurt, Germany.
Dominik Christian FuhrmannInstitute of Biochemistry I, Goethe-University, Medical Faculty, Frankfurt, Germany.
Dimitry NamgaladzeInstitute of Biochemistry I, Goethe-University, Medical Faculty, Frankfurt, Germany.
Ilka WittigFunctional Proteomics Group, Institute of Cardiovascular Physiology, Goethe-University, Medical Faculty, Frankfurt, Germany.
Irmgard TegederInstitute of Clinical Pharmacology, Goethe-University, Medical Faculty, Frankfurt, Germany. Electronic address: tegeder@em.uni-frankfurt.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleoredoxin is a thioredoxin-like redoxin that has been recognized as redox modulator of WNT signaling. Using a Yeast-2-Hybrid screen, we identified calcium calmodulin kinase 2a, Camk2a, as a prominent prey in a brain library. Camk2a is crucial for nitric oxide dependent processes of neuronal plasticity of learning and memory. Therefore, the present study assessed functions of NXN in neuronal Nestin-NXN

Indexed as

Exploratory BehaviorMotor ActivityAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2HippocampusMiceMice, Inbred C57BLMice, KnockoutNestinNeuronsOxidoreductasesCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseNes protein, mouseNestinnucleoredoxinOxidoreductasesBehaviorCalcium calmodulin kinaseIntelliCagePlayPleasureProteomicsRedoxin

Identifiers

PMID34198070
PMCPMC8254043

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.