ArticleEnvironment international2021
Cord serum elementomics profiling of 56 elements depicts risk of preterm birth: Evidence from a prospective birth cohort in rural Bangladesh.
Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Early Marriage, Preterm Birth, and School Dropout: An Intergenerational Cycle of Risk?American journal of human biology : the official journal of the Human Biology Council · 2025Pooled it
- Prenatal Cerium Exposure and Neural Tube Defect Risk: A Case-control Study in Shanxi, China.Biological trace element research · 2026Article
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- Toxic Trace Element Levels in Maternal and Cord Blood Worldwide and Their Impact on Pregnancy: A Narrative Review.Journal of xenobiotics · 2026Review
- Exposure-associated health implications of potentially toxic elements in maternal and umbilical cord blood at Ishaka adventist hospital, Bushenyi District, Uganda.Scientific reports · 2026Article
- CABIT: a novel biomarkers-integrated inflammatory risk tool for ischemic heart disease developed in the USA and prospectively validated in China.Journal of translational medicine · 2026Article
- Associations between prenatal metal exposure, gene variants, and birth size in Taiwan Birth Panel Study.Pediatric research · 2026Article
- Micronutrients in relation to cardiometabolic risk factors among middle-aged and older Chinese adults: protocol for an exploratory longitudinal panel study with multi-omics profiling.Frontiers in public health · 2026Article
- Levels of Cu, Zn, and Se in Maternal and Cord Blood in Normal and Pathological Pregnancies: A Narrative Review.International journal of molecular sciences · 2025Review
- Associations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis.Biological trace element research · 2025Article
- Gestational and Early Childhood Exposure to Barium and Cardiometabolic Risk in Preschoolers: Findings From the Ma'anshan Birth Cohort Study in China.Journal of the American Heart Association · 2025Article
- Joint effects of prenatal PMFrontiers in public health · 2025Article
- Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth.Maternal & child nutrition · 2024Article
- Association between Maternal Exposure to Arsenic during Pregnancy and Risk of Preterm Birth: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2024Review
- Association between light rare earth elements in maternal plasma and the risk of spontaneous preterm birth: a nested case-control study from the Beijing birth cohort study.Environmental health : a global access science source · 2023Article
- Article
- Individual and combined association between nutritional trace metals and the risk of preterm birth in a recurrent pregnancy loss cohort.Frontiers in nutrition · 2023Article
- Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: Evidence from a prospective birth cohort in rural Bangladesh.Environment international · 2022Article
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
Maternal exposure to some individual rare earth elements and trace elements is associated with preterm birth, but few elements have been studied and little is known about the potential effect of simultaneous exposure to multiple elements. We examined individual and mixture effects of elements on preterm birth among 745 pregnant women in a prospective birth cohort in Bangladesh (2008-2011). We measured 56 elements in umbilical cord blood collected during delivery using inductively coupled plasma-mass spectrometry. Using elastic net (ENET) regularization and multivariate logistic regression, we examined independent associations between element concentrations and preterm birth. Bayesian kernel machine regression identified mixture effects of elements most critical to preterm birth, accounting for correlated exposure and interaction. ENET identified titanium (Ti), arsenic (As), and barium (Ba) as the most important predictors of shortened gestational age and preterm birth. In adjusted models, cord blood Ti (OR = 2.52; 95% CI: 1.08-5.93; P = 0.033), As (odds ratio (OR) = 1.34; 95% CI: 1.04-1.73; P = 0.023), and Ba (OR = 1.18; 95% CI: 1.02-1.38; P = 0.029) were significantly associated with preterm birth. Bayesian kernel machine regression suggested an interaction effect between As and Ba. Further, we constructed an element risk score (ERS) using estimated weights from a multivariate regression model for Ti, As, and Ba and regressed preterm birth by this score (OR = 2.72, 95% CI: 1.57-4.69; P = 3.35 × 10
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