Evidence map›Paper›PMID 34197703›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2021

Polycythemia is Associated with Lower Incidence of Severe COPD Exacerbations in the SPIROMICS Study.

Ashraf Fawzy, Han Woo, Aparna Balasubramanian, Igor Barjaktarevic, R Graham Barr, Russell P Bowler, Alejandro P Comellas, Christopher B Cooper, David Couper, Gerard J Criner and 13 more

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01969344 active not recruitingnot on this map

Subpopulations and Intermediate Outcome Measures in COPD Study

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2010 to 2031Enrolled2,981ConditionsCOPD, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 1 country.

Ashraf FawzyDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Han WooDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Aparna BalasubramanianDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Igor BarjaktarevicDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States.
R Graham BarrDepartment of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States.
Russell P BowlerDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado, United States.
Alejandro P ComellasDivision of Pulmonary, Critical Care, and Occupational Medicine, College of Medicine, University of Iowa, Iowa City, Iowa, United States.
Christopher B CooperDepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, United States.
David CouperDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Gerard J CrinerDepartment of Thoracic Surgery and Medicine, Temple University, Philadelphia, Pennsylvania, United States.
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Eric A HoffmanDepartment of Radiology, Medicine and Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States.
Richard E KannerDivision of Respiratory, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, Utah, United States.
Jerry A KrishnanDivision of Pulmonary, Critical Care, Sleep, and Allergy, University of Illinois at Chicago, Chicago, Illinois, United States.
Fernando J MartinezDivision of Pulmonology and Critical Care Medicine, Weill-Cornell Medical Center, Cornell University, New York, New York, United States.
Meredith McCormackDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Robert Paine IiiDivision of Respiratory, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, Utah, United States.
Stephen PetersSection on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University, Winston-Salem, North Carolina, United States.
Robert WiseDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Prescott G WoodruffDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Francisco, San Francisco, California, United States.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Nirupama PutchaDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States.
Johns Hopkins University · USUniversity of California, Los Angeles · USUniversity of Iowa · USUniversity of Utah · USColumbia University · USCornell University · USMichigan United · USNational Jewish Health · USTemple University · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Illinois Chicago · USUniversity of North Carolina at Chapel Hill · USWake Forest University · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Brandi Janssen · 1990 to 2026
$40.5M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
Platelet Activation Pathways and Respiratory Morbidity in COPDK23HL151758 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FAWZY, ASHRAF · 2021 to 2025
$986k
NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K23 HL151758NHLBI NIH HHS K23HL151758NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

Secondary polycythemia has long been recognized as a consequence of chronic pulmonary disease and hypoxemia and is associated with lower mortality and fewer hospitalizations among individuals with chronic obstructive pulmonary disease (COPD)-prescribed long-term oxygen therapy. This study investigates the association of polycythemia with COPD severity, phenotypic features, and respiratory exacerbations in a contemporary and representative sample of individuals with COPD. Current and former smokers with COPD (forced expiratory volume in 1 second [FEV

Indexed as

acute exacerbation of COPDpolycythemiaSPIROMICS

Identifiers

PMID34197703
PMCPMC8428597
OpenAlexW3176317627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.