Evidence map›Paper›PMID 34197688›Full record

Observational studyClinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery2021

Post-extubation dysphagia and dysphonia amongst adults with COVID-19 in the Republic of Ireland: A prospective multi-site observational cohort study.

Julie Regan, Margaret Walshe, Sarah Lavan, Eanna Horan, Patricia Gillivan Murphy, Anne Healy, Caoimhe Langan, Karen Malherbe, Breda Flynn Murphy, Maria Cremin and 3 more

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Long-term effects on swallowing and laryngeal function after treatment for severe COVID-19 disease in intensive care.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  7. Article
  8. Observational
  9. Dysphagia in post Covid-19 Patients- a Prospective Cohort Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  10. Article
  11. Clinical profile and recovery pattern of dysphagia in the COVID-19 patient: A prospective observational cohort within NSW.Australian critical care : official journal of the Confederation of Australian Critical Care Nurses · 2023
    Observational
  12. Article
  13. Article
  14. Article
  15. Sarcopenia and COVID-19 Outcomes.Clinical interventions in aging · 2023
    Review
  16. Review
  17. Review
  18. Dysphagia and mechanical ventilation in SARS-COV-2 pneumonia: It's real.Clinical nutrition (Edinburgh, Scotland) · 2022
    Observational
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julie ReganDepartment of Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland.ORCID 0000-0001-5816-4516
Margaret WalsheDepartment of Clinical Speech and Language Studies, Trinity College Dublin, Dublin, Ireland.
Sarah LavanSpeech and Language Therapy Department, St. James' Hospital, Dublin, Ireland.
Eanna HoranSpeech and Language Therapy Department, Tallaght University Hospital, Dublin, Ireland.
Patricia Gillivan MurphySpeech and Language Therapy Department, Mater Misericordiae University Hospital, Dublin, Ireland.
Anne HealySpeech and Language Therapy Department, Beaumont Hospital, Dublin, Ireland.
Caoimhe LanganSpeech and Language Therapy Department, St. Vincent's University Hospital, Dublin, Ireland.
Karen MalherbeSpeech and Language Therapy Department, Galway University Hospital, Galway, Ireland.
Breda Flynn MurphySpeech and Language Therapy Department, Midland Regional Hospital Tullamore & Portlaoise, Offaly, Ireland.
Maria CreminSpeech and Language Therapy Department, University Hospital Kerry, Tralee, Ireland.
Denise HiltonSpeech and Language Therapy Department, Cavan General Hospital, Cavan, Ireland.
Jenni CavaliereSpeech and Language Therapy Department, University Hospital Waterford, Waterford, Ireland.
Alice WhyteSpeech and Language Therapy Department, Naas General Hospital, Naas, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to (i) investigate post-extubation dysphagia and dysphonia amongst adults intubated with SARS-COV-2 (COVID-19) and referred to speech and language therapy (SLT) in acute hospitals across the Republic of Ireland (ROI) between March and June 2020; (ii) identify variables predictive of post-extubation oral intake status and dysphonia and (iii) establish SLT rehabilitation needs and services provided to this cohort.

designA multi-site prospective observational cohort study.

participantsOne hundred adults with confirmed COVID-19 who were intubated across eleven acute hospital sites in ROI and who were referred to SLT services between March and June 2020 inclusive.

main outcome measuresOral intake status, level of diet modification and perceptual voice quality.

resultsBased on initial SLT assessment, 90% required altered oral intake and 59% required tube feeding with 36% not allowed oral intake. Age (OR 1.064; 95% CI 1.018-1.112), proning (OR 3.671; 95% CI 1.128-11.943) and pre-existing respiratory disease (OR 5.863; 95% CI 1.521-11.599) were predictors of oral intake status post-extubation. Two-thirds (66%) presented with dysphonia post-extubation. Intubation injury (OR 10.471; 95% CI 1.060-103.466) and pre-existing respiratory disease (OR 24.196; 95% CI 1.609-363.78) were predictors of post-extubation voice quality. Thirty-seven per cent required dysphagia intervention post-extubation, whereas 20% needed intervention for voice. Dysphagia and dysphonia persisted in 27% and 37% cases, respectively, at hospital discharge. DISCUSSION: Post-extubation dysphagia and dysphonia were prevalent amongst adults with COVID-19 across the ROI. Predictors included iatrogenic factors and underlying respiratory disease. Prompt evaluation and intervention is needed to minimise complications and inform rehabilitation planning.

Indexed as

AdolescentAdultAgedAged, 80 and overAirway ExtubationCOVID-19Deglutition DisordersDysphoniaFemaleHumansIrelandMaleMiddle AgedProspective StudiesRisk FactorsSARS-CoV-2COVID-19dysphagiadysphoniaintubationpost-extubationspeech and language therapyswallowingvoice

Identifiers

PMID34197688
PMCPMC8444742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.