ArticlePloS one2021
Geographic variation in Alzheimer's disease mortality.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Alzheimer's disease and related dementias state policies and mortality in the United States: A descriptive study.Journal of Alzheimer's disease : JAD · 2026Article
- Alzheimer's disease risk prediction from clinical and social determinants of health: a machine learning cohort study in UK Biobank.BMJ health & care informatics · 2026Article
- Modeling the age-specific incidence of mild cognitive impairment incorporating the time-varying relationship of Alzheimer's disease biomarkers over 28 years.Journal of Alzheimer's disease : JAD · 2026Article
- Regional disparities in cognitive life expectancy: The role of birth and current residence in the United States.Health & place · 2025Article
- The role of educational attainment and quality in U.S. regional variation in prevalence of dementia and CIND.PloS one · 2025Article
- Variation in Adult Cognition Across Domains and Life Course Place Effects in the UK.Journal of aging and health · 2024Article
- Geographic disparities in Alzheimer's disease and related dementia mortality in the US: Comparing impacts of place of birth and place of residence.SSM - population health · 2024Article
- Geographic Patterns of Dementia in the United States: Variation by Place of Residence, Place of Birth, and Subpopulation.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Regional variation in U.S dementia trends from 2000-2012.SSM - population health · 2022Article
- The rising burden of Alzheimer's disease mortality in rural America.SSM - population health · 2022Article
- Geospatial and temporal disparities in Alzheimer's disease deaths in Argentina.Journal of Alzheimer's disease reportsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveAccumulating evidence suggests the possibility that early life exposures may contribute to risk of Alzheimer's Disease (AD). This paper explores geographic disparities in AD mortality based on both state of residence in older age as well as state of birth measures in order to assess the relative importance of these factors.
methodsWe use a subset of a large survey, the NIH-AARP Diet and Health Study, of over 150,000 individuals aged 65-70 with 15 years of mortality follow-up, allowing us to study over 1050 cases of AD mortality. We use multi-level logistic regression, where individuals are nested within states of residence and/or states of birth, to assess the contributions of place to AD mortality variation.
resultsWe show that state of birth explains a modest amount of variation in AD mortality, approximately 4%, which is consistent with life course theories that suggest that early life conditions can produce old age health disparities. However, we also show that nearly all of the variation from state of birth is explained by state of residence in old age.
conclusionsThese results suggest that later life factors are potentially more consequential targets for intervention in reducing AD mortality and provide some evidence against the importance of macro-level environmental exposures at birth as a core determinant of later AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.