Evidence map›Paper›PMID 34197462›Full record

ArticlePLoS computational biology2021

POMAShiny: A user-friendly web-based workflow for metabolomics and proteomics data analysis.

Pol Castellano-Escuder, Raúl González-Domínguez, Francesc Carmona-Pontaque, Cristina Andrés-Lacueva, Alex Sánchez-Pla

Abstract read
In one paragraph

Article in PLoS computational biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Journal of proteome research · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. CURTAIN-A unique web-based tool for exploration and sharing of MS-based proteomics data.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. A fat- and sucrose-enriched diet causes metabolic alterations in mdx mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Article
  17. Article
  18. Journal of proteome research · 2023
    Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pol Castellano-EscuderBiomarkers and Nutritional & Food Metabolomics Research Group, Department of Nutrition, Food Science and Gastronomy, Food Innovation Network (XIA), University of Barcelona, Barcelona, Spain.ORCID 0000-0001-6466-877X
Raúl González-DomínguezBiomarkers and Nutritional & Food Metabolomics Research Group, Department of Nutrition, Food Science and Gastronomy, Food Innovation Network (XIA), University of Barcelona, Barcelona, Spain.ORCID 0000-0002-7640-8833
Francesc Carmona-PontaqueStatistics and Bioinformatics Research Group, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain.
Cristina Andrés-LacuevaBiomarkers and Nutritional & Food Metabolomics Research Group, Department of Nutrition, Food Science and Gastronomy, Food Innovation Network (XIA), University of Barcelona, Barcelona, Spain.ORCID 0000-0002-8494-4978
Alex Sánchez-PlaStatistics and Bioinformatics Research Group, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-8673-7737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolomics and proteomics, like other omics domains, usually face a data mining challenge in providing an understandable output to advance in biomarker discovery and precision medicine. Often, statistical analysis is one of the most difficult challenges and it is critical in the subsequent biological interpretation of the results. Because of this, combined with the computational programming skills needed for this type of analysis, several bioinformatic tools aimed at simplifying metabolomics and proteomics data analysis have emerged. However, sometimes the analysis is still limited to a few hidebound statistical methods and to data sets with limited flexibility. POMAShiny is a web-based tool that provides a structured, flexible and user-friendly workflow for the visualization, exploration and statistical analysis of metabolomics and proteomics data. This tool integrates several statistical methods, some of them widely used in other types of omics, and it is based on the POMA R/Bioconductor package, which increases the reproducibility and flexibility of analyses outside the web environment. POMAShiny and POMA are both freely available at https://github.com/nutrimetabolomics/POMAShiny and https://github.com/nutrimetabolomics/POMA, respectively.

Indexed as

InternetSoftwareData Interpretation, StatisticalMetabolomicsProteomicsReproducibility of Results

Identifiers

PMID34197462
PMCPMC8279420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.