ArticlePLoS biology2021
D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost-benefit evaluation and motivation in monkeys.
Article in PLoS biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Ventrolateral prefrontal cortex in macaques guides decisions in different learning conditions.Nature communications · 2026Article
- Article
- Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Pharmacological Modulation of Dopamine Receptors Reveals Distinct Brain-Wide Networks Associated with Learning and Motivation in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Noradrenergic and Dopaminergic modulation of meta-cognition and meta-control.PLoS computational biology · 2025Article
- Pharmacological modulation of dopamine receptors reveals distinct brain-wide networks associated with learning and motivation in non-human primates.bioRxiv : the preprint server for biology · 2024Article
- Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number.Psychopharmacology · 2024Review
- Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys.PLoS biology · 2024Article
- PET-measured human dopamine synthesis capacity and receptor availability predict trading rewards and time-costs during foraging.Nature communications · 2023Article
- Cognitive effects of thalamostriatal degeneration are ameliorated by normalizing striatal cholinergic activity.Science advances · 2023Article
- Striatal Dopamine Transporter Availability Is Not Associated with Food Craving in Lean and Obese Humans; a Molecular Imaging Study.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost-benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.