ArticleBrain pathology (Zurich, Switzerland)2021
Does etiology really matter for epilepsy surgery outcome?
Article in Brain pathology (Zurich, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Microbiota-gut-brain axis and treatment resistance in epilepsy: a multicentre prospective study protocol (CARE).BMJ open · 2026Trial
- Fully automated three-dimensional deep learning-based magnetic resonance imaging segmentation of brain cavities in epilepsy surgery.Epilepsia · 2026Article
- Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Optimizing the diagnostic timing for drug-resistant epilepsy: balancing timeliness and stability with an antiseizure medication waiting period.Therapeutic advances in neurological disorders · 2026Article
- Seminars in epileptology: Presurgical epilepsy evaluation.Epileptic disorders : international epilepsy journal with videotape · 2025Review
- Space- and object-based attention in patients with a single hemisphere following childhood resection.Scientific reports · 2025Article
- Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection.iScience · 2024Article
- Surgical outcomes of drug-refractory infantile epileptic spasms syndrome and related prognostic factors: a retrospective study.Acta epileptologica · 2024Article
- Simulated resections and RNS placement can optimize post-operative seizure outcomes when guided by fast ripple networks.medRxiv : the preprint server for health sciences · 2024Article
- Fully automatic segmentation of brain lacunas resulting from resective surgery using a 3D deep learning model.medRxiv : the preprint server for health sciences · 2024Article
- Simulated resections and responsive neurostimulator placement can optimize postoperative seizure outcomes when guided by fast ripple networks.Brain communications · 2024Article
- Deep histopathology genotype-phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb.Acta neuropathologica communications · 2023Article
- Clinical and Surgical Approach for Cerebral Cortical Dysplasia.Advances and technical standards in neurosurgery · 2023Article
- Detection of brain somatic mutations in focal cortical dysplasia during epilepsy presurgical workup.Brain communications · 2023Article
- Frontal lobe seizures: overview and update.Journal of neurology · 2022Review
- Neuropathology and epilepsy surgery: 2022 update.Free neuropathology · 2022Article
- An introduction to the mini-symposium on "The Neuropathology of Focal Human Epilepsy".Brain pathology (Zurich, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Multiple factors influence the outcomes of epilepsy surgery. Prognostic indicators varying from clinical characteristics, imaging findings, ictal, and interictal electrophysiological activity have been linked to surgical outcomes. In this review, we focus on the relatively under-studied role of the underlying epilepsy histopathology in driving post-surgical outcomes, specifically focusing on the broad categories of seizure outcomes and cognitive outcomes. For each of these two outcomes of interest, we answer two questions: 1)- does etiology matter? and 2)- how could it matter? The goal is to review the existing literature on the relationship between etiology and surgical outcomes to provide the best possible judgment as to whether a causal relationship exists between histopathology and the ultimate surgical outcome as an initial step. Then, we delve into the possible mechanisms via which such relationships can be explained. We conclude with a call to action to the epilepsy surgery and histopathology research community to push the mechanistic understanding of the pathology-outcome interaction and identify actionable knowledge and biomarkers that could inform patient care in a timely fashion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.