Evidence map›Paper›PMID 34196980›Full record

Trial reportInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2022

Anti-hypertensive use for non-severe gestational hypertension in Botswana: A case-control study.

Katherine M Johnson, Rebecca Zash, Anna M Modest, Rebecca Luckett, Modiegi Diseko, Mompati Mmalane, Joseph Makhema, Doreen Ramogola-Masire, Blair J Wylie, Roger Shapiro

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Katherine M JohnsonDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0002-5127-8139
Rebecca ZashDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Anna M ModestDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Rebecca LuckettDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Modiegi DisekoBotswana-Harvard Partnership, Gaborone, Botswana.
Mompati MmalaneBotswana-Harvard Partnership, Gaborone, Botswana.
Joseph MakhemaBotswana-Harvard Partnership, Gaborone, Botswana.
Doreen Ramogola-MasireBotswana-Harvard Partnership, Gaborone, Botswana.
Blair J WylieDepartment of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Roger ShapiroDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Beth Israel Deaconess Medical Center · USBotswana Harvard AIDS Institute Partnership · BWUniversity of Botswana · BW

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Botswana Birth Outcomes Surveillance ExtensionR01HD095766 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHAPIRO, ROGER L · 2018 to 2022
$3.3M
Birth Outcomes Surveillance in BotswanaR01HD080471 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHAPIRO, ROGER L · 2014 to 2018
$2.6M
Expansion of research and mentoring to improve birth outcomes and treatment outcomes among HIV-affected children in BotswanaK24AI131924 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Roger L Shapiro · 2018 to 2026
$1.6M
Decreasing Adverse Birth Outcomes among HIV-infected Women on Antiretroviral TherapyK23HD088230 · NICHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ZASH, REBECCA MARIE · 2017 to 2021
$820k
Harvard UniversityNational Institutes of Health/National Institute of Child Health and Human Development K23HD088230National Institutes of Health/National Institute of Child Health and Human Development R01HD080471National Institutes of Health/National Institute of Child Health and Human Development R01HD095766NCATS NIH HHS UL1 TR002541NIAID NIH HHS K24 AI131924NICHD NIH HHS K23 HD088230NICHD NIH HHS R01 HD080471NICHD NIH HHS R01 HD095766
6 · The paper itself

Abstract

objectiveThe fetal risks and benefits of antihypertensives to treat gestational hypertension in pregnancy are understudied, particularly in low- and middle-income countries.

methodsWe performed a nested case-control study within a retrospective cohort of obstetrical patients in Botswana from 2014 to 2019. We included women carrying singletons who developed new onset non-severe hypertension (140-159 mm Hg systolic or 90-109 mm Hg diastolic blood pressure) after 20 weeks of pregnancy. Cases were defined as women with either small-for-gestational-age (SGA) infants or stillbirth, analyzed separately; controls were otherwise similar women without the adverse outcome in each analysis.

resultsWe identified 1932 cases of SGA (7925 controls) and 316 cases of stillbirth (9619 controls). Cases with SGA were more likely to have used an anti-hypertensive than controls (33% vs 29%, adjusted odds ratio [aOR] 1.28, 95% confidence interval [CI] 1.15-1.43). Cases with stillbirth were more likely to have used an anti-hypertensive than controls (42% versus 29%, aOR 1.45, 95% CI 1.14-1.83).

conclusionAnti-hypertensive use for new-onset gestational hypertension was associated with an increased risk of having an SGA infant or a stillbirth among women who never developed severe hypertension. These data support conduct of a randomized clinical trial to determine the appropriate use of anti-hypertensives in non-severe gestational hypertension.

Indexed as

Hypertension, Pregnancy-InducedAntihypertensive AgentsBotswanaCase-Control StudiesFemaleHumansInfantInfant, NewbornInfant, Small for Gestational AgePregnancyRetrospective StudiesAntihypertensive Agentsanti-hypertensiveshypertensive disorders of pregnancylow- and middle-income countriessmall for gestational agestillbirth

Identifiers

PMID34196980
PMCPMC8855659
OpenAlexW3177170530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.