Evidence map›Paper›PMID 34196965›Full record

Trial reportAnaesthesia2021

Impact of the pericapsular nerve group (PENG) block on postoperative analgesia and functional recovery following total hip arthroplasty: a randomised, observer-masked, controlled trial.

G Pascarella, F Costa, R Del Buono, R Pulitanò, A Strumia, C Piliego, E De Quattro, R Cataldo, F E Agrò, M Carassiti and 1 more

12 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 12 registered trials, which are not on this map. Cited by 91 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04388553 nacompletednot on this map

Single Shot Lumbar Erector Spinae Plane (ESP) Block in Total Hip Replacement (THR): a Randomized Control Trial

TypeinterventionalSponsorTuen Mun HospitalRan2020 to 2021Enrolled71ConditionsTotal Hip Replacement, AnalgesiaArmssingle shot lumbar Erector Spinae Plane block
NCT05056675 nacompletednot on this mapstarted 2022, after this paper: background citation

The PENG Block in Elective Hip Surgery and Its Effect on Postoperative Pain and Length of Stay: A Multidisciplinary Prospective Randomized Double-blind Controlled Trial.

TypeinterventionalSponsorHôpital FribourgeoisRan2022 to 2023Enrolled151ConditionsPain, PostoperativeArmsPENG block, Placebo
NCT05256056 nacompletednot on this mapstarted 2022, after this paper: background citation

Comparison of the Volume Dependent Effect of Pericapsular Nerve Block in Patients Operated for Femur Fracture: A Randomized Prospective Study

TypeinterventionalSponsorSisli Hamidiye Etfal Training and Research HospitalRan2022 to 2022Enrolled60ConditionsPost Operative Pain, Femur FractureArmsBupivacain
NCT05432011 nacompletednot on this mapstarted 2022, after this paper: background citation

PENG Block Combined to Lateral Femoral Cutaneous Nerve Block vs. PENG Block Combined to Wound Infiltration for Postoperative Analgesia Following Posterolateral-approached Total Hip Arthroplasty

TypeinterventionalSponsorCampus Bio-Medico UniversityRan2022 to 2023Enrolled50ConditionsPain, Postoperative Pain, Acute Pain, AnalgesiaArmsPENG Block, Lateral Femoral Cutaneous Nerve Block, Wound Infiltration
NCT05477641 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Analgesic Comparison of Pericapsular Nerve Group (PENG) Block and Lateral Femoral Cutaneous Nerve (LFCN) Block to Fascia Iliaca Compartment Block (FICB) in Patients Undergoing Primary Total Hip Arthroplasty (THA).

TypeinterventionalSponsorSSM Health Bone and Joint Hospital at St AnthonyRan2022 to 2023Enrolled105ConditionsAnalgesiaArmsPericapsular Nerve Group Block with Lateral Femoral Cutaneous Nerve Block, Fascia Iliaca Compartment Block
NCT05773365 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Evaluation of Analgesic Effect of Added Local Infiltration to Pericapsular Nerve Group Block in Traumatic Hip Surgery

TypeinterventionalSponsorSuez Canal UniversityRan2023 to 2025Enrolled122ConditionsPain, Hip Fractures, Postoperative Pain, Postoperative AnalgesiaArmsPENG block with or without local anaesthetic infiltration
NCT05916209 completednot on this mapstarted 2023, after this paper: background citation

Pericapsular Nerve Group (PENG) Block and Lateral Femoral Cutaneous Nerve (LFCN) Block Versus Fascia Iliaca (FIC) Block for Multimodal Analgesia After Total Hip Replacement Surgery: a Retrospective Analysis

TypeobservationalSponsorOspedale Edoardo BassiniRan2023 to 2023Enrolled60ConditionsRegional Anesthesia Morbidity, Arthropathy of Hip, Hip ArthropathyArmsPeripheral nerve blocks
NCT05974423 phase4unknown statusnot on this mapstarted 2022, after this paper: background citation

Prospective Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation Following a Labrum Repair

TypeinterventionalSponsorThe Cooper Health SystemRan2022 to 2025Enrolled60ConditionsPostoperative Pain, Acute, Opioid Use, Labral Tear, GlenoidArmsTylenol, Ibuprofen, and Oxycodone, Tylenol and Ibuprofen only
NCT06166602 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparison of the Impacts of Ultrasound-guided Pericapsular Nerve Group (PENG) Block Applied in Different Volumes on Postoperative Pain in Hip Replacement Surgeries: A Randomized Clinical Trial

TypeinterventionalSponsorIstanbul Medeniyet UniversityRan2023 to 2023Enrolled50ConditionsRegional Anesthesia, Postoperative Pain, Hip SurgeryArmsPENG block with 0.25% bupivacaine.
NCT06317870 narecruitingnot on this mapstarted 2024, after this paper: background citation

Pericapsular Nerve Block Versus Intrathecal Morphine for Analgesia After Primary Hip Arthroplasty: a Double Blind, Non-inferiority Study

TypeinterventionalSponsorCentre Hospitalier Universitaire VaudoisRan2024 to 2027Enrolled80ConditionsAnalgesia, Hip Arthropathy, Post Operative PainArmsIntrathecal morphine, Pericapsular nerve group block (PENG)
NCT06821516 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of Analgesic Effectiveness Between Pericapsular Nerve Group (PENG) Block and Lumbar Erector Spinae Plane Block in Patients Undergoing Total Hip Arthroplasty With Spinal Anesthesia: a Randomized Controlled Trial

TypeinterventionalSponsorBaşakşehir Çam & Sakura City HospitalRan2025 to 2026Enrolled52ConditionsOpioid Consumption, Postoperative, Pain, Postoperative, Nerve Block, PENG BlockArmsEvaluation of the postoperative analgesic effectiveness of PENG block in participants undergoing total hip arthroplasty under spinal anesthesia, Evaluation of the postoperative analgesic effectiveness of lumbar erector spinae block in participants undergoing total hip arthroplasty under spinal anesthesia
NCT07040423 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of Local Anesthetic Distribution in the PENG Block Compartment Using Pelvic MRI

TypeinterventionalSponsorCampus Bio-Medico UniversityRan2025 to 2026Enrolled6ConditionsTotal Hip Arthroplasty (THA), Postoperative Pain Management After Total Hip ArthroplastyArmsPENG Block, Magnetic resonance imaging
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pericapsular nerve group block for total hip arthroplasty: A systematic review.The Journal of international medical research · 2026
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

G PascarellaUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
F CostaUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
R Del BuonoUnit of Anesthesia, Intensive Care and Pain Management, ASST Gaetano Pini, Milan, Italy.
R PulitanòUnit of Anesthesia, Intensive Care and Pain Management, Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
A StrumiaUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
C PiliegoUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
E De QuattroUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
R CataldoUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
F E AgròUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
M CarassitiUnit of Anesthesia, Intensive Care and Pain Management, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pericapsular nerve group (PENG) block is a novel regional anaesthesia technique that aims to provide hip analgesia with preservation of motor function, although evidence is currently lacking. In this single-centre, observer-masked, randomised controlled trial, patients undergoing total hip arthroplasty received pericapsular nerve group block or no block (control group). Primary outcome measure was maximum pain scores (0-10 numeric rating scale) measured in the first 48 h after surgery. Secondary outcomes included postoperative opioid consumption; patient mobilisation assessments; and length of hospital stay. Sixty patients were randomly allocated equally between groups. The maximum pain score of patients receiving the pericapsular nerve group block was significantly lower than in the control group at all time-points, with a median (IQR [range]) of 2.5 (2.0-3.7 [0-7]) vs. 5.5 (5.0-7.0 [2-8]) at 12 h; 3 (2.0-4.0 [0-7]) vs. 6 (5.0-6.0 [2-8]) at 24 h; and 2.0 (2.0-4.0 [0-5]) vs. 3.0 (2.0-4.7 [0-6]) at 48 h; all p < 0.001. Moreover, the pericapsular nerve group showed a significant reduction in opioid consumption, better range of hip motion and shorter time to ambulation. Although no significant difference in hospital length of stay was detected, our results suggest improved postoperative functional recovery following total hip arthroplasty in patients who received pericapsular nerve group block.

Indexed as

AgedAnalgesics, OpioidAnesthesia, LocalArthroplasty, Replacement, HipHumansLength of StayMaleMiddle AgedNauseaNerve BlockPain ManagementPostoperative PainPostoperative PeriodAnalgesics, Opioidanaesthesiaanalgesiaarthroplastyhip surgerypostoperative pain

Identifiers

PMID34196965
PMCPMC8519088

What OpenQuestion holds

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Registered trials

and 6 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.