ArticleAging clinical and experimental research2022
Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study.
Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Inflammatory Biomarkers and Gait Impairment in Older Adults: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Adaptogenic Effects of Mushroom Blend Supplementation on Stress, Fatigue, and Sleep: A Randomised, Double-Blind, and Placebo-Controlled Trial.Brain and behavior · 2026Trial
- Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults.The journal of nutrition, health & aging · 2022Trial
- Observational
- Article
- Fatigue as a mediator between multidimensional influencing factors and lower limb function in older adults based on the theory of unpleasant symptoms.BMC geriatrics · 2025Article
- Relationship between physical function and quality of life based on treatment timing in patients with advanced lung cancer.Journal of physical therapy science · 2025Article
- Inflammation is associated with pain and fatigue in older adults.Brain, behavior, & immunity - health · 2024Article
- Study on the balance and gait characteristics of subjects with generalized joint hypermobility residing in high-altitude using wearable devices: a cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Associations of mid-to-late-life inflammation with late-life mobility and the influences of chronic comorbidities, race, and social determinants of health: The Atherosclerosis Risk in Communities Study.Journal of the American Geriatrics Society · 2024Article
- Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment.Aging and disease · 2024Review
- The Longitudinal Association between Multiple Frailty Criteria and Depressive Symptomatology Five Years Later in Older Adults: A Decision Tree Modelling Approach.Journal of clinical medicine · 2024Article
- Association of Physical Activity and Exercise with Physical Performance and Muscle Mass in Older Adults: Results from the Longevity Check-Up (Lookup) 7+ Project.Journal of clinical medicine · 2023Article
- CRP, but not fibrinogen, is associated with gait speed as early as middle age, in females but not males.Scientific reports · 2023Article
- Fatigue and Physical Activity in People after COVID-19 in Poland.Journal of personalized medicine · 2023Article
- Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease.Aging clinical and experimental research · 2022Article
- Inflammatory cytokines and sarcopenia in Iranian adults-results from SARIR study.Scientific reports · 2022Article
- Daily Physical Activity Patterns as a Window on Cognitive Diagnosis in the Baltimore Longitudinal Study of Aging (BLSA).Journal of Alzheimer's disease : JAD · 2022Article
- A pilot study of the moderating effect of gender on the physical activity and fatigue severity among recovered COVID-19 patients.PloS one · 2022Article
- Association Between Fatigue and Falls Risk Among the Elderly Aged Over 75 Years in China: The Chain Mediating Role of Falls Efficacy and Lower Limb Function.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundFatigue, inflammation, and physical activity (PA) are all independently associated with gait speed, but their directionality is not fully elucidated.
aimsEvaluate the bidirectional associations amongst fatigue, inflammation, and PA on gait speed.
methodsThis cross sectional study included probands (n = 1280, aged 49-105) and offspring (n = 2772, aged 24-88) in the Long Life Family Study. We assessed gait speed, fatigue with the question "I could not get going", inflammation using fasting interleukin-6 (IL-6) and high sensitivity C-reactive protein (CRP), and self-reported PA as walking frequency in the past two weeks. The two generations were examined separately using linear mixed modeling.
resultsLower fatigue, lower IL-6, and greater PA were all associated with faster gait speed in both generations (all p < 0.05); lower CRP was only associated with faster gait speed in the offspring. PA explained the association of fatigue and gait speed via a 16.1% (95% CI 9.7%, 26.7%) attenuation of the direct associations for the probands and 9.9% (95% CI 6.3%, 18.8%) in the offspring. In addition, IL-6 explained more of the association of fatigue and gait speed than the association between PA and gait speed, via a 14.9% (95% CI 9.2%, 23.4%) attenuation of the direct association in the offspring only. DISCUSSION: Results revealed a potential directionality from fatigue to IL-6 to PA that may lead to faster gait speed. Future work should examine these relationships longitudinally to establish temporality and causality.
conclusionsOur findings support a signal that lowering fatigue and inflammation and increasing physical activity may delay functional decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.