Trial reportGeroScience2021
Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.
Trial report in GeroScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Optimal resistance training strategies for knee osteoarthritis symptom relief: a systematic review and network meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Mechanical, Material and Morphological Adaptations of Healthy Lower Limb Tendons to Mechanical Loading: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The Effect of Eccentric vs. Traditional Resistance Exercise on Muscle Strength, Body Composition, and Functional Performance in Older Adults: A Systematic Review With Meta-Analysis.Frontiers in sports and active living · 2022Pooled it
- Hydrolysed Collagen Supplementation Enhances Patellar Tendon Adaptations to 12 Weeks' Resistance Training in Middle-Aged Men.European journal of sport science · 2025Trial
- Effect of eccentric training at different muscle lengths on the gastrocnemius medialis fascicle behaviour during single and multi-joint tasks.European journal of applied physiology · 2026Article
- Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026Review
- Eccentric vs. Concentric Training: A Systematic Review and Meta-Analysis of Randomized Controlled Trials on Performance and Health Benefits Across Diverse Populations.Sports (Basel, Switzerland) · 2026Review
- Effects of resistance exercises on rotator cuff muscle mechanical characteristics in shoulders with and without rotator cuff tears.PloS one · 2026Article
- Muscle or Fascial System Lesion (Part II): The Medial Gastrocnemius and the "Tennis Leg" Paradigm.Cureus · 2025Review
- Comparison between concentric-eccentric and concentric-only plantar flexor exercise training with body weight for changes in muscle strength, range of motion, and muscle architecture.European journal of applied physiology · 2025Article
- Submaximal Eccentric Training During Immobilization Does Not Prevent Serial Sarcomere Loss or Impairments in Mechanical Function in Old or Young Rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Exploring the biomechanics and fatigue patterns of eccentric quasi-isometric muscle actions in the knee extensors and flexors.European journal of applied physiology · 2024Article
- The Effect of Bone Mechanical Stress Caused by Electrical Stimulation-Induced Muscle Contraction on Osteocalcin Secretion.Biology · 2024Article
- Submaximal eccentric resistance training increases serial sarcomere number and improves dynamic muscle performance in old rats.Physiological reports · 2024Article
- Structure and function of Achilles and patellar tendons following moderate slow resistance training in young and old men.European journal of applied physiology · 2024Article
- Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats.Skeletal muscle · 2024Article
- The Biomechanics of Musculoskeletal Tissues during Activities of Daily Living: Dynamic Assessment Using Quantitative Transmission-Mode Ultrasound Techniques.Healthcare (Basel, Switzerland) · 2024Review
- Impaired lower limb muscle mass, quality and function in end stage liver disease: A cross-sectional study.Experimental physiology · 2023Article
- Muscle-tendon unit design and tuning for power enhancement, power attenuation, and reduction of metabolic cost.Journal of biomechanics · 2023Review
- Age-related changes in gait biomechanics and their impact on the metabolic cost of walking: Report from a National Institute on Aging workshop.Experimental gerontology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Resistance exercise training (RET) is well-known to counteract negative age-related changes in both muscle and tendon tissue. Traditional RET consists of both concentric (CON) and eccentric (ECC) contractions; nevertheless, isolated ECC contractions are metabolically less demanding and, thus, may be more suitable for older populations. However, whether submaximal (60% 1RM) CON or ECC contractions differ in their effectiveness is relatively unknown. Further, whether the time course of muscle and tendon adaptations differs to the above is also unknown. Therefore, this study aimed to establish the time course of muscle and tendon adaptations to submaximal CON and ECC RET. Twenty healthy young (24.5 ± 5.1 years) and 17 older males (68.1 ± 2.4 years) were randomly allocated to either isolated CON or ECC RET which took place 3/week for 8 weeks. Tendon biomechanical properties, muscle architecture and maximal voluntary contraction were assessed every 2 weeks and quadriceps muscle volume every 4 weeks. Positive changes in tendon Young's modulus were observed after 4 weeks in all groups after which adaptations in young males plateaued but continued to increase in older males, suggesting a dampened rate of adaptation with age. However, both CON and ECC resulted in similar overall changes in tendon Young's modulus, in all groups. Muscle hypertrophy and strength increases were similar between CON and ECC in all groups. However, pennation angle increases were greater in CON, and fascicle length changes were greater in ECC. Notably, muscle and tendon adaptations appeared to occur in synergy, presumably to maintain the efficacy of the muscle-tendon unit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.