Observational studyClinical and experimental nephrology2021
Incidence, risk factors and outcome of acute kidney injury (AKI) in patients with COVID-19.
Observational study in Clinical and experimental nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Global geographic and socioeconomic disparities in COVID-associated acute kidney injury: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Acute kidney injury outcomes in covid-19 patients: systematic review and meta-analysis.Jornal brasileiro de nefrologiaPooled it
- Electronic Phenotype for Detection, Staging, and Subtyping of Acute Kidney Injury.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Article
- Diabetes Mellitus and Multidrug-Resistant Gram-Negative Bacterial Infections in Critically Ill COVID-19 Patients: A Retrospective Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
- Impact of Preoperative COVID-19 on Postoperative Outcomes in Patients Undergoing Bariatric/Metabolic Surgery: an Updated Analysis of TrinetX Databases.Obesity surgery · 2025Article
- Observational
- Prevalence of Acute Renal Failure, Para-Clinical Outcomes, and Mortality in COVID-19 Patients.Clinical medicine & research · 2024Article
- The relation between proteinuria and the severity of COVID-19.Clinical and experimental nephrology · 2024Article
- Outcome Comparison in Hospitalized COVID-19 Patients With and Without AKI.Journal of community hospital internal medicine perspectives · 2024Article
- [Severe post-COVID-19 dialysis dependence and inpatient acute kidney injury].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
- Incidence of, and Risk Factors and Outcomes Associated with, Acute Kidney Injury in COVID-19 at the National Kidney and Transplant Institute, Philippines.Tropical medicine and infectious disease · 2023Article
- Factors Predictive of Development of Acute Kidney Injury in Patients With COVID-19 in Brunei Darussalam.Cureus · 2023Article
- Machine learning for acute kidney injury: Changing the traditional disease prediction mode.Frontiers in medicine · 2023Review
- Acute Kidney Injury Among Admitted COVID-19 Patients in Addis Ababa, Ethiopia.International journal of nephrology and renovascular disease · 2023Article
- COVID-19 Infection in Chronic Kidney Disease Patients in Bulgaria: Risk Factors for Death and Acute Kidney Injury.Journal of personalized medicine · 2022Article
- COVID-19 death and kidney disease in a multiracial Asian country.Nephrology (Carlton, Vic.) · 2022Observational
- Evolving Risk of Acute Kidney Injury in COVID-19 Hospitalized Patients: A Single Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2022Article
- Using dipstick urinalysis to predict development of acute kidney injury in patients with COVID-19.BMC nephrology · 2022Article
- Awaiting a cure for COVID-19: therapeutic approach in patients with different severity levels of COVID-19.Le infezioni in medicina · 2022Review
- A Prospective Study on Risk Factors for Acute Kidney Injury and All-Cause Mortality in Hospitalized COVID-19 Patients From Tehran (Iran).Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
23 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is a severe complication of coronavirus disease-2019 (COVID-19). This study aims to evaluate incidence, risk factors and case-fatality rate of AKI in patients with COVID-19.
methodsWe reviewed the health medical records of 307 consecutive patients with COVID-19 hospitalized at the University Hospital of Modena, Italy.
resultsAKI was diagnosed in 69 out of 307 (22.4%) COVID-19 patients. Stages 1, 2, or 3 AKI accounted for 57.9%, 24.6% and 17.3%, respectively. AKI patients had a mean age of 74.7 ± 9.9 years. These patients showed higher serum levels of the main markers of inflammation and higher rate of severe pneumonia than non-AKI patients. Kidney injury was associated with a higher rate of urinary abnormalities including proteinuria (0.44 ± 0.85 vs 0.18 ± 0.29 mg/mg; P = < 0.0001) and microscopic hematuria (P = 0.032) compared to non-AKI patients. Hemodialysis was performed in 7.2% of the subjects and 33.3% of the survivors did not recover kidney function after AKI. Risk factors for kidney injury were age, male sex, CKD and higher non-renal SOFA score. Patients with AKI had a mortality rate of 56.5%. Adjusted Cox regression analysis revealed that COVID-19-associated AKI was independently associated with in-hospital death (hazard ratio [HR] = 4.82; CI 95%, 1.36-17.08) compared to non-AKI patients.
conclusionAKI was a common and harmful consequence of COVID-19. It manifested with urinary abnormalities (proteinuria, microscopic hematuria) and conferred an increased risk for death. Given the well-known short-term sequelae of AKI, prevention of kidney injury is imperative in this vulnerable cohort of patients.
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