ArticleApplied microbiology and biotechnology2021
Geraniol eradicates Candida glabrata biofilm by targeting multiple cellular pathways.
Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Study of Human Antimicrobial Peptides Active Against Some Bacteroidota Species of the Oral Cavity.Antibiotics (Basel, Switzerland) · 2026Article
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- Mechanism of azole resistance inJournal of medical microbiology · 2025Article
- Synthesis of Chitosan based nanoemulsions and their characterization and antifungal activity toward fungi causing mucormycosis.Scientific reports · 2025Article
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- Unveiling novel insights: geraniol's enhanced anti-candida efficacy and mechanistic innovations against multidrug-resistant candida strains.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Geraniol Potentiates the Effect of Fluconazole against Planktonic and Sessile Cells of Azole-ResistantPharmaceutics · 2024Article
- Abrogation of efflux pump activity, biofilm formation, and immune escape by candidacidal geraniol in emerging superbug, Candida auris.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Biochemical and metabolomic insights into antifungal mechanism of berberine against Candida glabrata.Applied microbiology and biotechnology · 2023Article
- Regulatory role of Mss11 inFrontiers in cellular and infection microbiology · 2023Article
- Azole-Based Compounds That Are Active againstAntibiotics (Basel, Switzerland) · 2022Article
- Antifungal, Antioxidant and Antibiofilm Activities of Essential Oils ofAntibiotics (Basel, Switzerland) · 2022Article
- Molecular investigations onRSC advances · 2022Article
- Elucidating the Eradication Mechanism of Perillyl Alcohol againstACS bio & med chem Au · 2022Article
- Geraniol inhibits biofilm formation of methicillin-resistantFrontiers in microbiology · 2022Article
- Natural Compounds: A Hopeful Promise as an Antibiofilm Agent AgainstFrontiers in pharmacology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Global burden of fungal infections and associated health risk has accelerated at an incredible pace and needs to be attended at the earliest with an unbeatable therapeutic intervention. Candida glabrata is clinically the most relevant and least drug susceptible Candida species. In the pursuit of mining alternative novel drug candidates, the antifungal activity of a monoterpene phytoactive molecule geraniol (GR) against C. glabrata biofilm was evaluated. Biofilm inhibitory and eradication ability of GR evaluated against C. glabrata along with its clinical isolates. Impact of GR on various cellular pathways was evaluated to delineate its antifungal mode of action. GR has inhibited both planktonic and sessile growth of all the studied C. glabrata strains and eradicated the mature biofilm. GR reduced the carbohydrate and eDNA content, as well as hydrolytic enzyme activity in extracellular matrix of C. glabrata. The chemical profiling, microscopic, and spectroscopic studies revealed that GR targets chitin and β-glucan in cell wall. Further, results highlighted the reduction of cell membrane ergosterol content, and blocking of ABC drug efflux pump by GR which was also confirmed by RT-PCR where expression of CDR1 and ERG4 was downregulated in GR exposed C. glabrata cells. The fluorescence microscopy and flow cytometry results emphasized the alteration in mitochondrial activity, increased Ca
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