Evidence map›Paper›PMID 34196588›Full record

Trial reportPharmaceutical biology2021

Thermoregulatory effects of guava leaf extract-menthol toner application for post-exercise use.

Titeyut Wongsanao, Wipavadee Leemingsawat, Vipaporn Panapisal, Thanomwong Kritpet

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Pharmaceutical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Bioactive Compounds from Guava Leaves (Molecules (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Titeyut WongsanaoFaculty of Sports Science, Chulalongkorn University, Bangkok, Thailand.ORCID https://orcid.org/0000-0003-0252-9752
Wipavadee LeemingsawatFaculty of Sports Science, Chulalongkorn University, Bangkok, Thailand.ORCID https://orcid.org/0000-0001-8259-3847
Vipaporn PanapisalDepartment of Pharmaceutics and Industrial Pharmacy and Cosmetics Strategic Research Unit, Chulalongkorn University Drug and Health Products Innovation & Promotion Center, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-6244-7962
Thanomwong KritpetFaculty of Sports Science, Chulalongkorn University, Bangkok, Thailand.ORCID https://orcid.org/0000-0001-8800-6754
Chulalongkorn University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

context

objectiveThis study investigates the influence of guava leaf extract-menthol toner on thermoregulation, including perspiration, skin temperature, and recovery heart rate. MATERIALS AND

methodsThis randomised, placebo-controlled clinical trial assessed the effects of the guava leaf extract-menthol toner and placebo with a 1-week washout period. Sixty-four participants were enrolled. The participants exercised on a treadmill until a 75% heart rate reserve was achieved for 5 min, followed by a 5 min post-exercise rest period. The skin temperature and heart rate were then measured before 5 mL of the testing product was sprayed to specific areas of the body, left it for 30 sec before wiped off. Post-exercise perspiration and skin temperatures were collected by sweat patches and measured by the Skin-thermometer ST500, respectively. A 20 min heart rate monitoring period started 10 min after the exercise and measured every 2 min intervals.

resultsUse of the toner significantly reduced post-exercise perspiration to approximately half of the baseline and placebo use values ( DISCUSSION AND

conclusionGuava leaf extract-menthol toner reduced perspiration by astringent effects but did not influence heat dissipation and did not affect cardiovascular mechanism compared to the controls. Additional cleaning with guava leaf extract-menthol toner could offer better hygiene after a workout.

Indexed as

AdolescentBody Temperature RegulationCross-Over StudiesExerciseExercise TestFemaleHeart RateHumansMaleMentholPlant ExtractsPlant LeavesPsidiumSingle-Blind MethodSkin TemperatureSweatingMentholPlant ExtractsAstringentheat dissipationpersonal hygieneskin temperaturesweating

Identifiers

PMID34196588
PMCPMC8253185
OpenAlexW3175211342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.