Evidence map›Paper›PMID 34196481›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Suction Cups-Inspired Adhesive Patch with Tailorable Patterns for Versatile Wound Healing.

Rongkang Huang, Xiaoxuan Zhang, Wenzhao Li, Luoran Shang, Hui Wang, Yuanjin Zhao

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Growth-Like Swelling of 2D Precursors for Efficient Fabrication of Complex 3D Microstructures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Deformation Driven Suction Cups: A Mechanics-Based Approach to Wearable Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Octopus-Inspired Soft Robot for Slow Drug Release.Biomimetics (Basel, Switzerland) · 2024
    Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Multi-Bioinspired Functional Conductive Hydrogel Patches for Wound Healing Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  16. Article
  17. Article
  18. Application of Biomedical Microspheres in Wound Healing.International journal of molecular sciences · 2023
    Review
  19. Advances in dermatological application of GelMA hydrogel microneedles.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rongkang HuangDepartment of Colorectal Surgery and Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, Sixth Affiliated Hospital of Sun Yat-sen University, Guangdong, 510655, China.ORCID 0000-0002-9499-0222
Xiaoxuan ZhangDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.
Wenzhao LiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, 999077, China.
Luoran ShangZhongshan-Xuhui Hospital, The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Hui WangDepartment of Colorectal Surgery and Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology, Sixth Affiliated Hospital of Sun Yat-sen University, Guangdong, 510655, China.
Yuanjin ZhaoDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, China.

Funding

National Key Research and Development Program of China 2020YFA0908200National Natural Science Foundation of China 52073060National Natural Science Foundation of China 61927805Natural Science Foundation of Jiangsu BE2018707
6 · The paper itself

Abstract

Medical patches play an important role in wound healing because of their tissue conformality, drug release capacity, and convenient operation. Great efforts have been devoted to developing new-generation patches with distinctive features promoting wound healing. Here, inspired by the structure of octopus suction cups and the component of natural tissue, a biocompatible wound patch with selective adhesiveness and individualized design using a combined strategy of template-replication and mask-guided lithography is presented. Such patches are based on Ecoflex film with suction-cup-mimicking microstructures to adhere to normal skin and with biocompatible gelatin methacryloyl (GelMA) hydrogel to contact wounded areas. An ultraviolet mask with a tailorable pattern is employed to shape the GelMA hydrogel into customized geometry replicating individual wound areas, and thus both adhesion and antiadhesion properties are integrated into the same patch. In addition, vascular endothelial growth factor is loaded to accelerate the healing process. Based on these advantages, the authors demonstrate that the present patches not only adhere to different skin surfaces, but also promote the treatment of a rat cutaneous wound model. Thus, it is believed that this versatile patch can break through the limitation of traditional patches and be ideal candidates for wound healing and related biomedical applications.

Indexed as

AdhesivesGelatinMethacrylatesTransdermal PatchWound HealingAnimalsBiocompatible MaterialsEquipment DesignHydrogelsModels, AnimalRatsRats, Sprague-DawleySuctionVascular Endothelial Growth Factor AAdhesivesBiocompatible MaterialsGelatingelatin methacryloylHydrogelsMethacrylatesVascular Endothelial Growth Factor Abioinspired patchesbiomaterialsselective adhesiontailorable patternswound healing

Identifiers

PMID34196481
PMCPMC8425934

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.