ArticleJournal of clinical hypertension (Greenwich, Conn.)2021
A two-sample Mendelian randomization analysis of heart rate variability and cerebral small vessel disease.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Relationship between cerebral white matter hyperintensities and autonomic function in older individuals with cerebral small vessel disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Endocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Heart rate response and recovery during exercise and dementia risk: a prospective UK biobank study.Scientific reports · 2025Article
- Causal relationship between Alzheimer's disease and cerebral small vessel disease: a Mendelian randomization study.Translational psychiatry · 2025Article
- Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies.Frontiers in neuroscience · 2024Review
- Analysis of the Relationship between Recent Small Subcortical Infarcts and Autonomic Nervous Dysfunction.Current neurovascular research · 2024Article
- Different implications of daytime and nighttime heart rate variability on total burden of cerebral small vascular disease in patients with nondisabling ischemic cerebrovascular events.Frontiers in cardiovascular medicine · 2024Article
- Implication of heart rate variability on cerebral small vessel disease: A potential therapeutic target.CNS neuroscience & therapeutics · 2023Article
- Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults.Journal of sport and health science · 2023Article
- Causal inference on neuroimaging data with Mendelian randomisation.NeuroImage · 2022Review
- Relationship between heart rate variability and cognitive function in patients with enlarged perivascular space.Frontiers in aging neuroscience · 2022Article
- Cerebral small vessel disease and heart rate variability: A quest for nontraditional risk factors.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- A two-sample Mendelian randomization analysis of heart rate variability and cerebral small vessel disease.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- What comes first: Heart rate variability changes or insomnia? A causal investigation using Mendelian randomization.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral small vessel disease (cSVD) is correlated with a high risk of stroke and cognitive impairment. Previous studies between heart rate variability (HRV) and cSVD revealed paradoxical results. The authors aimed to investigate the relationship between HRV and cSVD using Mendelian randomization analysis. Genetic instruments for HRV were obtained from previous genome-wide association studies. They applied inverse variance-weighted analysis, weighted median analysis, simple median analysis, and Mendelian randomization-Egger regression to evaluate the associations of HRV with white matter hyperintensity (WMH) and small vessel stroke (SVS) in the UK Biobank neuroimaging dataset and the MEGASTROKE genome-wide association study dataset. Two genetically predicted traits of HRV (the root mean square of the successive differences of inter beat intervals [RMSSD] and the peak-valley respiratory sinus arrhythmia or high frequency power [pvRSA/HF]) were suggestively associated with WMH (β 0.26, 95% confidence interval [CI] 0.04-0.49, p = .02; β 0.14, 95% CI 0.02-0.27, p = .03, respectively). Genetically predicted traits of HRV were not significantly associated with SVS. This study provides genetic support for a suggestive causal effect of HRV (RMSSD, pvRSA/HF) on WMH but not SVS.
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