ReviewJournal of evolutionary biology2021
SARS-CoV-2 virulence evolution: Avirulence theory, immunity and trade-offs.
Review in Journal of evolutionary biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Virulent Parasites Emerge in Hosts With Rising Temperatures.Global change biology · 2026Article
- Comparing the Risk of SARS-CoV-2 Immune Resistance Evolving Across Regions in the Americas with Differing Approaches to Public Health.Pathogens (Basel, Switzerland) · 2026Article
- Fetal vascular malperfusion and other placental lesions in relation to maternal SARS-CoV-2 exposure: a case-control study.Frontiers in medicine · 2026Article
- Virulence evolution of a salmonid virus following a host jump.PLoS pathogens · 2025Article
- Review
- The PTP4A3 inhibitor KVX-053 reduces Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virulence, inflammation, and development of acute lung injury in K18-hACE2 mice.Respiratory research · 2025Article
- Utility of compartmental models to test the competing hypotheses of pathogen evolution and human intervention.Frontiers in public health · 2025Article
- Insights into the Replication Kinetics Profiles of Malaysian SARS-CoV-2 Variant Alpha, Beta, Delta, and Omicron in Vero E6 Cell Line.International journal of molecular sciences · 2024Article
- Evolutionary Invasion Analysis of Modern Epidemics Highlights the Context-Dependence of Virulence Evolution.Bulletin of mathematical biology · 2024Article
- An agent-based model with antibody dynamics information in COVID-19 epidemic simulation.Infectious Disease Modelling · 2023Article
- At the crossroads of epidemiology and biology: Bridging the gap between SARS-CoV-2 viral strain properties and epidemic wave characteristics.Biochimie · 2023Review
- Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies.Communications medicine · 2023Review
- Do pathogens always evolve to be less virulent? The virulence-transmission trade-off in light of the COVID-19 pandemic.Biologia futura · 2023Review
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- When might host heterogeneity drive the evolution of asymptomatic, pandemic coronaviruses?Nonlinear dynamics · 2023Article
- Correlates of Coronavirus Disease 2019 Inpatient Mortality at a Southern California Community Hospital With a Predominantly Hispanic/Latino Adult Population.Open forum infectious diseases · 2023Article
- The Impact of Demographic, Clinical Characteristics and the Various COVID-19 Variant Types on All-Cause Mortality: A Case-Series Retrospective Study.Diseases (Basel, Switzerland) · 2022Article
- Emergence and evolution of SARS-CoV-2 genetic variants during the Cuban epidemic.Journal of clinical virology plus · 2022Article
- The changing epidemiology of SARS-CoV-2.Science (New York, N.Y.) · 2022Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has led to a resurgence of the debate on whether host-parasite interactions should evolve towards avirulence. In this review, we first show that SARS-CoV-2 virulence is evolving, before explaining why some expect the mortality caused by the epidemic to converge towards that of human seasonal alphacoronaviruses. Leaning on existing theory, we then include viral evolution into the picture and discuss hypotheses explaining why the virulence has increased since the beginning of the pandemic. Finally, we mention some potential scenarios for the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.