Evidence map›Paper›PMID 34196167›Full record

ArticleHaematologica2021

IL4-STAT6 signaling induces CD20 in chronic lymphocytic leukemia and this axis is repressed by PI3Kδ inhibitor idelalisib.

Veronika Sandova, Gabriela Mladonicka Pavlasova, Vaclav Seda, Katerina Amruz Cerna, Sonali Sharma, Veronika Palusova, Yvona Brychtova, Sarka Pospisilova, Stacey M Fernandes, Anna Panovska and 5 more

Open access · goldAbstract readLetter
In one paragraph

Article in Haematologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. A cytokine receptor-targeting chimera toolbox for expanding extracellular targeted protein degradation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
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  9. Article
  10. Article
  11. NF-kB and the CLL microenvironment.Frontiers in oncology · 2023
    Review
  12. Review
  13. Review
  14. Article
  15. Dihydropyrazinoquinazolinones via SThe Journal of organic chemistry · 2022
    Article
  16. Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Veronika SandovaCentral European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Gabriela Mladonicka PavlasovaCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Vaclav SedaCentral European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Katerina Amruz CernaCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Sonali SharmaCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Veronika PalusovaCentral European Institute of Technology, Masaryk University, Brno, Czech Republic.
Yvona BrychtovaDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Sarka PospisilovaDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Stacey M FernandesDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Anna PanovskaDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Michael DoubekDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Matthew S DavidsDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jennifer R BrownDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Jiri MayerDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Marek MrazCentral European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Internal Medicine, Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic. marek.mraz@email.cz.
University Hospital Brno · CZCentral European Institute of Technology · CZCentral European Institute of Technology – Masaryk University · CZDana-Farber Cancer Institute · USMasaryk University · CZ

Funding

Unlocking the Potential of PI3K Inhibition in CLLR01CA213442 · NCI · DANA-FARBER CANCER INST · PI BROWN, JENNIFER R · 2017 to 2021
$2.9M
European Research Council 802644NCI NIH HHS R01 CA213442
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsLeukemia, Lymphocytic, Chronic, B-CellAntigens, CD20HumansInterleukin-4PurinesQuinazolinonesSTAT6 Transcription FactorAntigens, CD20Antineoplastic AgentsidelalisibInterleukin-4PurinesQuinazolinonesSTAT6 protein, humanSTAT6 Transcription Factor

Identifiers

PMID34196167
PMCPMC8561290
OpenAlexW3174860311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.