Evidence map›Paper›PMID 34196049›Full record

ArticleMagnetic resonance in medicine2021

Design and characterization of a 3D-printed axon-mimetic phantom for diffusion MRI.

Farah N Mushtaha, Tristan K Kuehn, Omar El-Deeb, Seyed A Rohani, Luke W Helpard, John Moore, Hanif Ladak, Amanda Moehring, Corey A Baron, Ali R Khan

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Farah N MushtahaCentre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, Canada.ORCID 0000-0001-8463-8906
Tristan K KuehnCentre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, Canada.
Omar El-DeebDepartment of Biology, Western University, London, Canada.
Seyed A RohaniSchool of Biomedical Engineering, Western University, London, Canada.
Luke W HelpardSchool of Biomedical Engineering, Western University, London, Canada.
John MooreImaging Research Laboratories, Robarts Research Institute, Western University, London, Canada.
Hanif LadakSchool of Biomedical Engineering, Western University, London, Canada.
Amanda MoehringDepartment of Biology, Western University, London, Canada.
Corey A BaronCentre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, Canada.ORCID 0000-0001-7343-5580
Ali R KhanCentre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, Canada.ORCID 0000-0002-0760-8647

Funding

CIHR
6 · The paper itself

Abstract

purposeTo introduce and characterize inexpensive and easily produced 3D-printed axon-mimetic diffusion MRI phantoms in terms of pore geometry and diffusion kurtosis imaging metrics.

methodsPhantoms were 3D-printed with a composite printing material that, after the dissolution of the polyvinyl alcohol, exhibits microscopic fibrous pores. Confocal microscopy and synchrotron phase-contrast micro-CT imaging were performed to visualize and assess the pore sizes. Diffusion MRI scans of four identical phantoms and phantoms with varying print parameters in water were performed at 9.4 T. Diffusion kurtosis imaging was fit to both data sets and used to assess the reproducibility between phantoms and effects of print parameters on diffusion kurtosis imaging metrics. Identical scans were performed 25 and 76 days later, to test their stability.

resultsSegmentation of pores in three microscopy images yielded a mean, median, and SD of equivalent pore diameters of 7.57 μm, 3.51 μm, and 12.13 μm, respectively. Phantoms had T

conclusionThree-dimension-printed axon-mimetic phantoms can mimic the fibrous structure of axon bundles on a microscopic scale, serving as complex, anisotropic diffusion MRI phantoms.

Indexed as

AxonsDiffusion Magnetic Resonance ImagingPhantoms, ImagingPrinting, Three-DimensionalReproducibility of Resultsdiffusion MRImodeling and analysisvalidation

Identifiers

PMID34196049
PMCPMC8596689

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.