Evidence map›Paper›PMID 34196034›Full record

ArticleClinical transplantation2021

Variations in deceased donor kidney procurement biopsy practice patterns: A survey of U.S. organ procurement organizations.

Brendan R Emmons, S Ali Husain, Kristen L King, Joel T Adler, Sumit Mohan

Abstract read
In one paragraph

Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Evaluation of kidney procurement biopsy and machine perfusion on allograft outcomes: A retrospective cohort study of the Organ Procurement and Transplantation Network database.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  3. Proteinuria in Deceased Diabetic Donors and Kidney Transplant Outcomes.Canadian journal of kidney health and disease · 2026
    Article
  4. Article
  5. The pre-implantation biopsy story is not over yet.The Lancet regional health. Europe · 2025
    Article
  6. Article
  7. Deceased donor kidneys from higher distressed communities are significantly less likely to be utilized for transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brendan R EmmonsDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0003-3563-6124
S Ali HusainDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-1823-0117
Kristen L KingDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.
Joel T AdlerDepartment of Surgery, Division of Transplant Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8190-3444
Sumit MohanDepartment of Medicine, Division of Nephrology, Columbia University Medical Center, New York, New York, USA.ORCID 0000-0002-5305-9685

Funding

Institutional Career Development CoreKL2TR001874 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GENKINGER, JEANINE M., SHIMBO, DAICHI · 2016 to 2025
$13.6M
5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116066 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sumit Mohan, Deirdre Sawinski · 2017 to 2026
$2.5M
Identifying and exploring solutions to the ethical challenges of ApoL1 testing of donors with recent African ancestry through mixed methods research with stakeholdersR01MD014161 · NIMHD · WASHINGTON UNIVERSITY · PI DUBOIS, JAMES M, MOHAN, SUMIT · 2019 to 2021
$1.2M
Increasing Minority Population Awareness through Community Teaching for Improved Organ Donation (IMPACT for Improved Organ Donation)R01DK114893 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOHAN, SUMIT · 2017 to 2021
$1.2M
NCATS NIH HHS KL2 TR001874NIDDK NIH HHS R01 DK114893NIDDK NIH HHS U01 DK116066NIMHD NIH HHS R01 MD014161
6 · The paper itself

Abstract

backgroundProcurement biopsies have become a common practice in the evaluation and allocation of deceased donor kidneys in the United States despite questions about their value and reproducibility. We sought to determine the extent of OPO-level differences in criteria used to decide which deceased donor kidneys undergo a procurement biopsy and to assess the degree of variability in procurement biopsy technique and interpretation across OPOs.

methodsEach of the country's 58 OPOs were invited to participate in the survey. OPOs were divided into two groups based on organ availability ratio and deceased donor kidney discard rate. RESULTS AND

conclusionsFifty-out-of-fifty-eight invited OPOs (86% response rate) responded to the survey between November 2020 and December 2020. Thirty (60%) OPOs reported that they have formal criteria for performing kidney procurement biopsy, but for 29 of these OPOs, transplant centers can request biopsy on kidneys that do not meet criteria. OPOs used a total of seven different variables and 12 different numerical thresholds to define impaired kidney function that would prompt a procurement biopsy. Additionally, wide variability was seen in biopsy technique and procedures for biopsy interpretation and reporting of findings to transplant programs. These findings identify a clear opportunity for standardization of procurement biopsies to best practices.

Indexed as

Tissue and Organ ProcurementBiopsyHumansKidneyReproducibility of ResultsTissue DonorsUnited Statesdeceased donor kidneykidney biopsykidney transplantationorgan procurement organizationorgan quality

Identifiers

PMID34196034
PMCPMC8556234

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.