Evidence map›Paper›PMID 34195915›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021

In vitro anti-Cryptococcus activity of diphenyl diselenide alone and in combination with amphotericin B and fluconazole.

Jéssica Louise Benelli, Vanice Rodrigues Poester, Lívia Silveira Munhoz, Gabriel Baracy Klafke, David A Stevens, Melissa Orzechowski Xavier

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jéssica Louise BenelliMycology Laboratory, College of Medicine, Federal University of Rio Grande, Campus Saúde, Visconde de Paranaguá 102, Centro, Rio Grande, Rio Grande do Sul, 96201-900, Brazil.ORCID http://orcid.org/0000-0002-9309-5349
Vanice Rodrigues PoesterMycology Laboratory, College of Medicine, Federal University of Rio Grande, Campus Saúde, Visconde de Paranaguá 102, Centro, Rio Grande, Rio Grande do Sul, 96201-900, Brazil.
Lívia Silveira MunhozMycology Laboratory, College of Medicine, Federal University of Rio Grande, Campus Saúde, Visconde de Paranaguá 102, Centro, Rio Grande, Rio Grande do Sul, 96201-900, Brazil.
Gabriel Baracy KlafkeMycology Laboratory, College of Medicine, Federal University of Rio Grande, Campus Saúde, Visconde de Paranaguá 102, Centro, Rio Grande, Rio Grande do Sul, 96201-900, Brazil.
David A StevensCalifornia Institute for Medical Research, San Jose, and Div. of Infectious Diseases and Geographic Medicine, Stanford Univ. Medical School, Stanford, CA, USA.
Melissa Orzechowski XavierMycology Laboratory, College of Medicine, Federal University of Rio Grande, Campus Saúde, Visconde de Paranaguá 102, Centro, Rio Grande, Rio Grande do Sul, 96201-900, Brazil. melissaxavierfurg@gmail.com.
Universidade Federal do Rio Grande · BRCalifornia Institute for Medical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptococcus is an encapsulated yeast that causes fungal meningitis, most commonly in HIV patients, with high mortality rates. Thus, the study of new treatment options is relevant. Antifungal activity of organoselenium compounds attributed to their pro-oxidative effect in fungal cells has been shown given that few data regarding its anti-Cryptococcus activity are available, this in vitro study was conducted with 40 clinical isolates of Cryptococcus neoformans. Diphenyl diselenide (DD) alone, and its interaction with amphotericin B or fluconazole, was tested by microdilution and checkerboard assays. All Cryptococcus neoformans were inhibited by DD in concentrations ≤ 32 μg/mL, and fungicidal concentrations were ≤ 64 μg/mL. Advantageous interaction between fluconazole occurred in 40% of the isolates, respectively. This study contributes with data of DD alone and in combination with classical drugs of choice for cryptococcosis treatment. Further studies focused on DD antifungal mechanism of action, and in vivo experiments are necessary.

Indexed as

Benzene DerivativesCryptococcosisCryptococcus neoformansOrganoselenium CompoundsAmphotericin BAntifungal AgentsFluconazoleHumansMicrobial Sensitivity TestsAmphotericin BAntifungal AgentsBenzene DerivativesdiphenyldiselenideFluconazoleOrganoselenium CompoundsAntifungal agentsCryptococcosisDiphenyl diselenideFungal meningitisOrganoselenium compounds

Identifiers

PMID34195915
PMCPMC8578231
OpenAlexW3173158550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.