Evidence map›Paper›PMID 34195685›Full record

ArticleCell reports. Medicine2021

Laura E Richert-Spuhler, Corinne M Mar, Paurvi Shinde, Feinan Wu, Ting Hong, Evan Greene, Sharon Hou, Katherine Thomas, Raphael Gottardo, Nelly Mugo and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  2. Review
  3. Genomic analyses identify 15 risk loci and revealProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

Laura E Richert-SpuhlerVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Corinne M MarDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Paurvi ShindeVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Feinan WuGenomics & Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ting HongDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Evan GreeneVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Sharon HouDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Katherine ThomasDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Raphael GottardoVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Nelly MugoDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Guy de BruynPerinatal HIV Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
Connie CelumDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Jared M BaetenDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Jairam R LingappaDepartment of Global Health, University of Washington, Seattle, WA 98104, USA.
Jennifer M LundVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Partners in Prevention HSV/HIV Transmission Study
and the Partners PrEP Study Teams
University of Washington · USFred Hutch Cancer Center · USUniversity of the Witwatersrand · ZA

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Identification of Novel Mucosal Immune Mechanisms Involved in Protection from HIV-1R01AI131914 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LINGAPPA, JAIRAM RAO, LUND, JENNIFER M · 2017 to 2021
$4.0M
Evaluating the relationship of CD101 and UBE2V1 to genital mucosal inflammationR01AI129715 · NIAID · UNIVERSITY OF WASHINGTON · PI LINGAPPA, JAIRAM RAO · 2017 to 2021
$3.6M
CD101 function, T regulatory cells and HIV-1 acquisition riskR21AI127156 · NIAID · UNIVERSITY OF WASHINGTON · PI LINGAPPA, JAIRAM RAO, LUND, JENNIFER M · 2016 to 2017
$466k
NCI NIH HHS P30 CA015704NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI129715NIAID NIH HHS R01 AI131914NIAID NIH HHS R21 AI127156NIAID NIH HHS T32 AI007140
6 · The paper itself

Abstract

We recently reported that the risk of sexually acquired HIV-1 infection is increased significantly by variants in the gene encoding CD101, a protein thought to modify inflammatory responses. Using blood samples from individuals with and without these variants, we demonstrate that

Indexed as

MutationAdultAntigens, CDB-LymphocytesCell LineageDendritic CellsFemaleGene Expression ProfilingGene Expression RegulationGenetic Predisposition to DiseaseHIV-1HIV InfectionsHumansImmunity, InnateImmunophenotypingMaleAntigens, CDCCR5 protein, humanCd101 protein, mouseCXCR4 protein, humanReceptors, CCR5Receptors, CXCR4CD101HIV acquisitionhost genetic variationimmune quiescenceinflammationinflammatory homeostasisT cell

Identifiers

PMID34195685
PMCPMC8233694
OpenAlexW3170113038

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.