ArticleCell reports. Medicine2021
Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration.
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Article in Cell reports. Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
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Who cites it
40 citing papers in PubMed, 55 citations in OpenAlex.
- Inhibition of DNA demethylation attenuates experimental necrotizing enterocolitis via suppression of TLR4-mediated inflammation.Research square · 2026Article
- Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.Nature communications · 2026Article
- Gut dysbiosis associated with neonatal respiratory distress syndrome and biological plausibility of disease-specific probiotic intervention: a translational study.Journal of translational medicine · 2026Article
- Blockade of NKp46⁻ CCR6⁻ ILC3 autophagy protects against necrotizing enterocolitis by restoring energy metabolism balance in mice.Nature communications · 2026Article
- Probiotic interventions maintain intestinal barrier function and alleviate necrotizing enterocolitis by inhibiting ferroptosis in intestinal PMN-MDSCs.Cell death & disease · 2026Article
- Biofilm state Limosilactobacillus reuteri modulates aryl hydrocarbon receptor activity and suppresses experimental necrotizing enterocolitis.Pediatric research · 2026Article
- Adding Fat to the Fire: Does Lipidated IL-22 Promote Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Immunomodulators?Digestive diseases and sciences · 2025Article
- Breast milk IgG engages the mouse neonatal immune system to instruct responses to gut antigens.Science (New York, N.Y.) · 2025Article
- Review
- Donor human milk pasteurization methods and the effect on milk components as they relate to Necrotizing enterocolitis.Seminars in fetal & neonatal medicine · 2025Review
- Epigenetic Insights Into Necrotizing Enterocolitis: Unraveling Methylation-Regulated Biomarkers.Inflammation · 2025Article
- Elevated DUOX2 levels correlate with necrotizing enterocolitis development.Frontiers in cellular and infection microbiology · 2025Article
- Type 3 immune response protects againstEmerging microbes & infections · 2024Article
- Prevention Strategies and Management of Necrotizing Enterocolitis.Current treatment options in pediatrics · 2024Article
- A human STAT3 gain-of-function variant drives local Th17 dysregulation and skin inflammation in mice.The Journal of experimental medicine · 2024Article
- IL-22 promotes mucin-type O-glycosylation and MATH1Cell reports · 2024Article
- The role of interleukin-22 in mammalian intestinal homeostasis: Friend and foe.Immunity, inflammation and disease · 2024Review
- Article
- Immunological aspects of necrotizing enterocolitis models: a review.Frontiers in immunology · 2024Review
- Role of innate T cells in necrotizing enterocolitis.Frontiers in immunology · 2024Review
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Authors and funding
19 authors at 5 institutions in 1 country.
Belgacem MihiDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Qingqing GongDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Lila S NolanDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sarah E GaleDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Martin GoreeDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Elise HuDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wyatt E LanikDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jamie M RimerDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Victoria LiuWashington University in St. Louis, St. Louis, MO 63130, USA.
Olivia B ParksUniversity of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Angela N LewisDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Pranjal AgrawalWashington University in St. Louis, St. Louis, MO 63130, USA.
Marie L LauryGenome Technology Access Center, McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
Pawan KumarDepartment of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, USA.
Elizabeth HuangDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Shay S BidaniDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cliff J LukeDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jay K KollsCenter for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA, USA.
Misty GoodDepartment of Pediatrics, Division of Newborn Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · USJames S. McDonnell Foundation · USStony Brook University · USTulane University · USUniversity of Pittsburgh · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MTraining of the Pediatric Physician-ScientistT32HD043010 · NICHD · WASHINGTON UNIVERSITY · PI MARK E. LOWE · 2002 to 2026
$6.4MNeonatal gut-on-a-chip platform for high content drug testing and precision medicineR01HD105301 · NICHD · WASHINGTON UNIVERSITY · PI GOOD, MISTY L, MAGNESS, SCOTT T · 2021 to 2024
$2.4MModulation of the Intestinal Immune Response in Necrotizing EnterocolitisR01DK118568 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2018 to 2022
$1.8MInhibitors of Intestinal Epithelial Cell Lysosomal-Mediated NecrosisR01DK114047 · NIDDK · WASHINGTON UNIVERSITY · PI LUKE, CLIFFORD JAMES, SILVERMAN, GARY ARTHUR · 2018 to 2021
$1.7MNovel Anti-Inflammatory Properties of Breast Milk in Necrotizing EnterocolitisK08DK101608 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2014 to 2017
$584kAryl hydrocarbon receptor signaling in the pathogenesis of necrotizing enterocolitisR03DK111473 · NIDDK · WASHINGTON UNIVERSITY · PI GOOD, MISTY L · 2017 to 2018
$153kNCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NICHD NIH HHS R01 HD105301NICHD NIH HHS T32 HD043010NIDDK NIH HHS K08 DK101608NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK114047NIDDK NIH HHS R01 DK118568NIDDK NIH HHS R03 DK111473
Abstract
Necrotizing enterocolitis (NEC) is a deadly intestinal inflammatory disorder that primarily affects premature infants and lacks adequate therapeutics. Interleukin (IL)-22 plays a critical role in gut barrier maintenance, promoting epithelial regeneration, and controlling intestinal inflammation in adult animal models. However, the importance of IL-22 signaling in neonates during NEC remains unknown. We investigated the role of IL-22 in the neonatal intestine under homeostatic and inflammatory conditions by using a mouse model of NEC. Our data reveal that
Indexed as
AnimalsAnimals, NewbornChemokine CXCL1Chemokine CXCL2Disease Models, AnimalEnterocolitis, NecrotizingGastrointestinal MicrobiomeGene Expression Regulation, DevelopmentalHumansInfant, NewbornInfant, Newborn, DiseasesInfant, PrematureInterleukin-1betaInterleukin-22InterleukinsIntestinal MucosaChemokine CXCL1Chemokine CXCL2Cxcl1 protein, mouseCxcl2 protein, mouseIL1B protein, mouseInterleukin-1betaInterleukin-22interleukin-22 receptorInterleukinsProtein IsoformsReceptors, InterleukinRecombinant Proteinsepithelial cellsinterleukin-22intestinal immunitymicrobiomenecrotizing enterocolitisneonatalregeneration
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