Evidence map›Paper›PMID 34195581›Full record

ArticleEClinicalMedicine2021

HIV-1 Transmission linkages among persons with incident infection to inform public health surveillance.

Ann M Dennis, Simon D W Frost, Kimberly Enders, Andrew E Cressman, Erik Volz, Nicole Adams, William C Miller, Myron S Cohen, Victoria Mobley, Erika Samoff and 1 more

Open access · goldAbstract read
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ann M DennisDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Simon D W FrostMicrosoft Research, Redmond, WA, United States.
Kimberly EndersDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Andrew E CressmanDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Erik VolzImperial College, London, United Kingdom.
Nicole AdamsDivision of Public Health, North Carolina Department of Health and Human Services, Raleigh, NC, United States.
William C MillerDepartment of Epidemiology, The Ohio State University, Columbus, OH, United States.
Myron S CohenDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Victoria MobleyDivision of Public Health, North Carolina Department of Health and Human Services, Raleigh, NC, United States.
Erika SamoffDivision of Public Health, North Carolina Department of Health and Human Services, Raleigh, NC, United States.
Joseph J EronDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
University of North Carolina at Chapel Hill · USNC Department of Health and Human Services · USImperial College London · GBMicrosoft (United States) · USThe Ohio State University · US

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Timely monitoring and response to HIV transmission networks for intensified preventionR01AI135970 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DENNIS, ANN · 2018 to 2022
$3.8M
Rapid Response to Incident HIV Infection through Social Network Strategies and Molecular Epidemiology to Inform Partner ServicesR01AI169602 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ann Dennis · 2022 to 2026
$3.6M
Medical Research Council MR/R015600/1NIAID NIH HHS P30 AI050410NIAID NIH HHS R01 AI135970NIAID NIH HHS R01 AI169602
6 · The paper itself

Abstract

backgroundWe evaluated features of HIV transmission networks involving persons diagnosed during incident HIV infection (IHI) to assess network-based opportunities to curtail onward transmission.

methodsTransmission networks were constructed using partial

findingsOf 4,405 HIV diagnoses 2014-2018 with sequences, there were 323 (7%) IHI index persons; most were male (88%), Black (65%), young (68% <30 years), and reported sex with men (MSM) risk (79%). Index persons were more likely to be cluster members compared to non-index persons diagnosed during the same period (72% vs. 49%)

interpretationIntegrating public health with molecular epidemiology, revealed that more than half of IHI have viral links to persons with previously diagnosed unsuppressed HIV infection which was largely unrecognized by traditional contact tracing. Enhanced partner services to support engagement and retention in HIV care and improved case finding supported by rapid phylogenetic analysis are tools to substantially reduce onward HIV transmission.

Identifiers

PMID34195581
PMCPMC8225702
OpenAlexW3174976756

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.