Evidence map›Paper›PMID 34195556›Full record

ArticleMayo Clinic proceedings. Innovations, quality & outcomes2021

Cancer Mortality Rates Increasing vs Cardiovascular Disease Mortality Decreasing in the World: Future Implications.

Karim ReFaey, Shashwat Tripathi, Sanjeet S Grewal, Adip G Bhargav, David J Quinones, Kaisorn L Chaichana, Samuel O Antwi, Leslie T Cooper, Fredric B Meyer, Roxana S Dronca and 2 more

Open access · goldAbstract read
In one paragraph

Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. A systematic review and meta-analysis of cardiovascular disease risk with degarelix and GnRH agonists in prostate cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
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  3. Review
  4. Single-Cell RNA Sequencing Reveals Granzyme KJournal of the American Heart Association · 2025
    Article
  5. In vitro evaluation of CeODaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2025
    Article
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  8. Review
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  10. Article
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  14. Article
  15. Potential for Cure by Stage across the Cancer Spectrum in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  16. Article
  17. Review
  18. Trends of antihypertensive use among patients with cancer and hypertension in the United States 2002-2019.International journal of cardiology. Cardiovascular risk and prevention · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Karim ReFaeyNeurologic Surgery Department, Mayo Clinic, Jacksonville, FL.
Shashwat TripathiNeurologic Surgery Department, Mayo Clinic, Jacksonville, FL.
Sanjeet S GrewalNeurologic Surgery Department, Mayo Clinic, Jacksonville, FL.
Adip G BhargavNeurologic Surgery Department, Mayo Clinic, Rochester, MN.
David J QuinonesFlorida State University, Tallahassee, FL.
Kaisorn L ChaichanaNeurologic Surgery Department, Mayo Clinic, Jacksonville, FL.
Samuel O AntwiDepartment of Health Sciences Research and Epidemiology, Mayo Clinic, Jacksonville, FL.
Leslie T CooperCardiology Department, Mayo Clinic, Jacksonville, FL.
Fredric B MeyerNeurologic Surgery Department, Mayo Clinic, Rochester, MN.
Roxana S DroncaHematology Oncology Department, Mayo Clinic, Jacksonville, FL.
Robert B DiasioMayo Clinic Cancer CenterMayo Clinic, Rochester, MN.
Alfredo Quinones-HinojosaNeurologic Surgery Department, Mayo Clinic, Jacksonville, FL.
Jacksonville College · USMayo Clinic · USMayo Clinic in Florida · USFlorida State University · USMayo Clinic in Arizona · USNeurotech (United States) · USNorthwestern University · USWinnMed · US

Funding

Intra-Operative, Label-Free Detection of Brain Cancer Infiltration with Quantitative Optical ImagingR01CA200399 · NCI · JOHNS HOPKINS UNIVERSITY · PI LI, XINGDE, QUINONES-HINOJOSA, ALFREDO · 2016 to 2020
$3.0M
A novel microfluidic device to predict brain cancer prognosis and response to therapyR01CA216855 · NCI · MAYO CLINIC JACKSONVILLE · PI KONSTANTOPOULOS, KONSTANTINOS, QUINONES-HINOJOSA, ALFREDO · 2018 to 2022
$2.4M
Nanoparticle Modified Human Fat Derived Mesenchymal Stem Cells for Brain Cancer (Change of Organization Application)R01CA195503 · NCI · MAYO CLINIC JACKSONVILLE · PI GREEN, JORDAN, QUINONES-HINOJOSA, ALFREDO · 2016 to 2020
$1.9M
Dynamics and Causal Functions of Large-Scale Cortical and Subcortical NetworksU01NS108916 · NINDS · WADSWORTH CENTER · PI WOLPAW, JONATHAN RICKEL · 2018 to 2019
$1.4M
Chemically produced neural progenitors as a delivery vehicle for anti-glioma therapyR43CA221490 · NCI · CELL REPROGRAMMING AND THERAPEUTICS, LLC · PI ALEXANIAN, ARSHAK R, QUINONES-HINOJOSA, ALFREDO · 2018 to 2018
$300k
NCI NIH HHS R01 CA195503NCI NIH HHS R01 CA200399NCI NIH HHS R01 CA216855NCI NIH HHS R43 CA221490NINDS NIH HHS U01 NS108916
6 · The paper itself

Abstract

objectiveTo highlight the current global trends in mortality for cardiovascular disease and cancer.

methodsThe World Health Organization and the World Bank DataBank databases were used to analyze mortality rates for cancer and cardiovascular disease by calculating age-standardized mortality rates (ASRs) from 2000 to 2015 for high-income, upper-middle-income, and lower-middle-income countries. Data for cancer mortality and population for 43 countries representing 5 of the 7 continents (except Australia and Antarctica) were analyzed.

resultsFrom 2000 to 2015, there was an increase in the ASR for cancer for both men and women irrespective of a country's income status, representing an overall 7% increase in cancer ASR (Pearson

conclusionWe suspect that because of early detection and targeted interventions, cardiovascular disease mortality rates have decreased during the past decade. On the basis of our results, cancer mortality rates continue to rise, with the projection of surpassing cardiovascular disease mortality rates in the near future.

Indexed as

ASR, age-standardized mortality rateGBD, Global Burden of DiseaseGNI, gross national incomeWHO, World Health Organization

Identifiers

PMID34195556
PMCPMC8240359
OpenAlexW3171567068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.