ArticleLaryngoscope investigative otolaryngology2021
Frey's syndrome: A review of the physiology and possible role of neurotrophic factors.
Article in Laryngoscope investigative otolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- The Auriculotemporal Nerve: A Comprehensive Review of Its Anatomical Variation and Clinical Manifestations.Laryngoscope investigative otolaryngology · 2025Review
- Auriculotemporal syndrome associated with a traumatic vaginal delivery at birth.BMJ case reports · 2023Article
- Frey's syndrome: A review of the physiology and possible role of neurotrophic factors.Laryngoscope investigative otolaryngology · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesFrey's syndrome (FS) describes the phenomenon of gustatory sweating and is a cause of significant social embarrassment for sufferers. It has been attributed to aberrant growth of parasympathetic salivatory fibers in the auriculotemporal nerve toward overlying sweat glands. However, the exact mechanism behind this growth is unknown. This review aims to expand and elucidate the theory of aberrant regeneration in FS.
methodsA review of the recent literature on nerve regeneration was conducted in order develop further insights into the etiology of both adult onset and pediatric FS.
resultsNeurturin, a neurotrophic factor released by both salivary and sweat glands, was identified as a possible key player in the etiology of FS.
conclusionFurther research into the role of neurturin could help to elucidate the pathogenic mechanisms underlying the condition and might reveal neurturin to be a potential target for pharmacological intervention. LEVEL OF EVIDENCE: NA (Basic Science Review).
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