Evidence map›Paper›PMID 34195355›Full record

ArticleAdvanced materials technologies2021

Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump.

Linda Waldherr, Maria Seitanidou, Marie Jakešová, Verena Handl, Sophie Honeder, Marta Nowakowska, Tamara Tomin, Meysam Karami Rad, Tony Schmidt, Joachim Distl and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Advanced materials technologies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

  1. Polyelectrolyte Design Principles for Electrophoretic Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Electrotherapies for Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Linda WaldherrGottfried Schatz Research Center - Biophysics Medical University of Graz Graz 8010 Austria.ORCID https://orcid.org/0000-0001-9817-1358
Maria SeitanidouLaboratory of Organic Electronics Department of Science and Technology Linköping University Norrköping 60174 Sweden.ORCID https://orcid.org/0000-0002-1487-9197
Marie JakešováLaboratory of Organic Electronics Department of Science and Technology Linköping University Norrköping 60174 Sweden.
Verena HandlDepartment of Neurosurgery Medical University of Graz Graz 8010 Austria.
Sophie HonederDiagnostic and Research Institute of Pathology Medical University of Graz Graz 8010 Austria.
Marta NowakowskaDepartment of Neurosurgery Medical University of Graz Graz 8010 Austria.
Tamara TominDiagnostic and Research Institute of Pathology Medical University of Graz Graz 8010 Austria.
Meysam Karami RadLaboratory of Organic Electronics Department of Science and Technology Linköping University Norrköping 60174 Sweden.
Tony SchmidtGottfried Schatz Research Center - Biophysics Medical University of Graz Graz 8010 Austria.
Joachim DistlGottfried Schatz Research Center - Biophysics Medical University of Graz Graz 8010 Austria.
Ruth Birner-GruenbergerDiagnostic and Research Institute of Pathology Medical University of Graz Graz 8010 Austria.
Gord von CampeDepartment of Neurosurgery Medical University of Graz Graz 8010 Austria.
Ute SchäferDepartment of Neurosurgery Medical University of Graz Graz 8010 Austria.
Magnus BerggrenLaboratory of Organic Electronics Department of Science and Technology Linköping University Norrköping 60174 Sweden.
Beate RinnerDivision of Biomedical Research Medical University of Graz Graz 8036 Austria.
Martin AsslaberDiagnostic and Research Institute of Pathology Medical University of Graz Graz 8010 Austria.
Nassim Ghaffari-Tabrizi-WizsyOtto Loewi Research Center - Immunology and Pathophysiology Medical University of Graz Graz 8010 Austria.
Silke PatzDepartment of Neurosurgery Medical University of Graz Graz 8010 Austria.
Daniel T SimonLaboratory of Organic Electronics Department of Science and Technology Linköping University Norrköping 60174 Sweden.
Rainer SchindlGottfried Schatz Research Center - Biophysics Medical University of Graz Graz 8010 Austria.ORCID https://orcid.org/0000-0003-0896-8887
Medical University of Graz · ATLinköping University · SETU Wien · AT

Funding

Austrian Science Fund FWF TAI 245Austrian Science Fund FWF W 1226
6 · The paper itself

Abstract

Successful treatment of glioblastoma multiforme (GBM), the most lethal tumor of the brain, is presently hampered by (i) the limits of safe surgical resection and (ii) "shielding" of residual tumor cells from promising chemotherapeutic drugs such as Gemcitabine (Gem) by the blood brain barrier (BBB). Here, the vastly greater GBM cell-killing potency of Gem compared to the gold standard temozolomide is confirmed, moreover, it shows neuronal cells to be at least 10

Indexed as

electrophoretic drug deliverygemcitabineglioblastoma multiformeorganic electronic ion pumps

Identifiers

PMID34195355
PMCPMC8218220
OpenAlexW3155123426

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.