Evidence map›Paper›PMID 34195277›Full record

ArticleBioMed research international2021

lncRNA LINC01296 Promotes Oral Squamous Cell Carcinoma Development by Binding with SRSF1.

Yanhui Zhang, Aifang Wang, Xiaohe Zhang, Xiaoliang Wang, Jin Zhang, Jinji Ma

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yanhui ZhangDepartment of Stomatology, Jinan Central Hospital Affiliated to Shandong University, Jinan, China.
Aifang WangDepartment of Stomatology, Jinan Eighth People's Hospital, Jinan, China.
Xiaohe ZhangDepartment of Oral Disease Gaoxin Branch, Jinan Stomatological Hospital, Jinan, China.
Xiaoliang WangDepartment of Oral Disease Gaoxin Branch, Jinan Stomatological Hospital, Jinan, China.
Jin ZhangDepartment of Oral Disease Gaoxin Branch, Jinan Stomatological Hospital, Jinan, China.
Jinji MaDepartment of Oral Disease Gaoxin Branch, Jinan Stomatological Hospital, Jinan, China.ORCID https://orcid.org/0000-0002-5778-7188
Jinan Stomatological Hospital · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck, with strong local invasiveness and cervical lymph node metastasis. The purpose of this study was to investigate the role of LINC01296 in oral squamous cell carcinoma and its possible mechanism. MATERIALS AND

methodsGEPAI database analysis and clinical samples were used to detect the expression of LINC01296 in head and neck cancer. In vivo experiment, MTT, clone formation assay, and transwell were used to detect the proliferation, migration, and invasion of oral squamous cell carcinoma. The effect of LINC01296 on EMT was detected by western blot and qRT-PCR to measure the expression of epithelial and mesenchymal phenotypic markers. BALB/c nude mice were used to carry out in vitro treatment experiment. In terms of mechanism, the binding relationship between LINC01296 and SRSF1 was predicted and verified by the RBPDB database and RNA pull-down assay.

resultsLINC01296 was highly expressed in clinical samples and cell lines of oral squamous cell carcinoma. Overexpression of LINC01296 promoted the proliferation, invasion, and migration of oral squamous cell carcinoma cells and accelerated the formation of xenografts, while silencing LINC01296 inhibited tumor progression. In mechanism, LINC01296 plays a tumor-promoting role by binding to SRSF1 protein.

conclusionLINC01296 promotes malignant lesions in oral squamous cell carcinoma by binding to SRSF1 protein, which provides important experimental data and theoretical basis for the prevention, diagnosis, and treatment of oral squamous cell carcinoma.

Indexed as

AgedAnimalsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansLymphatic MetastasisMaleMiceMice, Inbred BALB CMice, NudeMiddle AgedMouth NeoplasmsNeoplasm InvasivenessLINC01296 long non-coding RNA, humanRNA, Long NoncodingSerine-Arginine Splicing FactorsSRSF1 protein, humanSrsf1 protein, mouse

Identifiers

PMID34195277
PMCPMC8214489
OpenAlexW3173126027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.