ArticleERJ open research2021
Microbial and clinical factors are related to recurrence of symptoms after childhood lower respiratory tract infection.
Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Corynebacterium pseudodiphtheriticum as etiologic agent of human infections worldwide: a review of case reports within the last 40 years (1983-2023).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Review
- Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus.Nature communications · 2024Article
- Dolosigranulum pigrum: A promising nasal probiotic candidate.PLoS pathogens · 2024Article
- Benchmarking laboratory processes to characterise low-biomass respiratory microbiota.Scientific reports · 2021Article
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Childhood lower respiratory tract infections (LRTI) are associated with dysbiosis of the nasopharyngeal microbiota, and persistent dysbiosis following the LRTI may in turn be related to recurrent or chronic respiratory problems. Therefore, we aimed to investigate microbial and clinical predictors of early recurrence of respiratory symptoms as well as recovery of the microbial community following hospital admission for LRTI in children. To this end, we collected clinical data and characterised the nasopharyngeal microbiota of 154 children (4 weeks-5 years old) hospitalised for a LRTI (bronchiolitis, pneumonia, wheezing illness or mixed infection) at admission and 4-8 weeks later. Data were compared to 307 age-, sex- and time-matched healthy controls. During follow-up, 66% of cases experienced recurrence of (mild) respiratory symptoms. In cases with recurrence of symptoms during follow-up, we found distinct nasopharyngeal microbiota at hospital admission, with higher levels of
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