ArticleFrontiers in nutrition2021
Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice.
Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Citrus Essential Oils: A Review of Chemical Composition, Bioactivity, Safe Use, and Potential Applications.Chemistry & biodiversity · 2026Review
- Histology of Pompia Peel and Bioactivity of Its Essential Oil: A New Citrus-Based Approach to Skin Regeneration.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Metalomics Revealed that Changes of Serum Elements were Associated with Oxidative Stress-Induced Inflammation of Cortex in a Mouse Model of Autism.Biological trace element research · 2025Article
- Antioxidant, Anti-Inflammatory, and Anticancer Activities of Five Citrus Peel Essential Oils.Antioxidants (Basel, Switzerland) · 2024Article
- Physicochemical properties and fatty acid profile of oil extracted from black soldier fly larvae (Veterinary world · 2024Article
- Bergaptol, a Major Furocoumarin in Citrus: Pharmacological Properties and Toxicity.Molecules (Basel, Switzerland) · 2024Review
- A Review on the Morphology, Cultivation, Identification, Phytochemistry, and Pharmacology ofMolecules (Basel, Switzerland) · 2023Review
- Chemical Composition of Essential Oils and Supercritical Carbon Dioxide Extracts fromMolecules (Basel, Switzerland) · 2023Article
- Emerging Insights into the Applicability of Essential Oils in the Management of Acne Vulgaris.Molecules (Basel, Switzerland) · 2023Review
- Comparison of Chemical Compositions and Antioxidant Activity of Essential Oils from Litsea Cubeba, Cinnamon, Anise, and Eucalyptus.Molecules (Basel, Switzerland) · 2023Article
- The Chemical Composition and Antibacterial and Antioxidant Activities of Five Citrus Essential Oils.Molecules (Basel, Switzerland) · 2022Article
- Microencapsulation of Essential Oils: A Review.Polymers · 2022Review
- Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals.Oxidative medicine and cellular longevity · 2022Review
- Volatile Compounds and Antioxidant and Antimicrobial Activities of Selected Citrus Essential Oils Originated from Nepal.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to analyze the non-volatile composition and antioxidant differences of lemon essential oils (LEOs) obtained by cold-pressing vs. hydrodistillation. Pathological observations showed that LEO effectively inhibited liver injury caused by oxidative stress, and CPLEO was more effective than HDLEO. CPLEO increased serum T-AOC, SOD, GSH, and GSH-Px levels while decreasing NO, COX-2, IL-6, IL-1β, IFN-γ, and TNF-α levels in mice with oxidative damage. The effects of CPLEO were stronger than those of HDLEO and similar to those of vitamin C. CPLEO upregulated mRNA and protein expressions of Cu/Zn-SOD, Mn-SOD, CAT, HO-1, Nrf2, and NQO1 while downregulating nNOS, iNOS, IL-1β, COX-2, TNF-α, and NF-κB mRNA expression and nNOS, eNOS, iNOS, and COX-2 protein expression in mice with oxidative damage. The results demonstrate that LEO has good antioxidant effects and that CPLEO has a better antioxidant effect than HDLEO as it retains more active non-volatile substances.
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