ReviewCanadian journal of gastroenterology & hepatology2021
Molecular Pathogenesis of Intrahepatic Cholestasis of Pregnancy.
Review in Canadian journal of gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The severity of intrahepatic cholestasis of pregnancy and its association with pregnancy complications and neonatal asphyxia: A single-center case analysis and systematic review.Biomolecules & biomedicine · 2024Pooled it
- Pooled it
- Early Precise Prediction and Severe Risk Stratification of Intrahepatic Cholestasis of Pregnancy: Advances and Future Directions in Clinical Translation from Traditional Models to Artificial Intelligence and Multi-Omics Technologies.Journal of clinical medicine · 2026Review
- Increased point shear wave elastography values of the placenta, fetal lung, and fetal liver in patients with intrahepatic cholestasis of pregnancy.BMC pregnancy and childbirth · 2026Article
- Maternal Serum SIRT1 Concentrations in Intrahepatic Cholestasis of Pregnancy: Limited Diagnostic Utility in a Prospective Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- The Role of the Delta Neutrophil Index in Determining the Severity of Intrahepatic Cholestasis of Pregnancy.Saudi medical journal · 2026Article
- Cholestatic and autoimmune liver diseases, bile duct injury, oxidative stress, and therapeutic strategies.Frontiers in physiology · 2026Review
- Predicting Intrahepatic Cholestasis of Pregnancy: A Retrospective Cohort Study of a Comprehensive Clinical Prediction Model.International journal of general medicine · 2026Article
- Impact of intrahepatic cholestasis of pregnancy on neonatal respiratory outcomes (CHOLE-RESP): protocol for a prospective cohort study.Frontiers in pediatrics · 2026Article
- Effect of vaginal estrogen supplementation for luteal phase support in the GnRH antagonist protocol on pregnancy outcomes for IVF/ICSI cycles: a randomized controlled trial.Human reproduction open · 2026Article
- Integrated untargeted and targeted metabolomics identifies and validates urinary bile acid biomarkers for the diagnosis of intrahepatic cholestasis of pregnancy.Frontiers in endocrinology · 2026Article
- Observational
- An unusual case of Kippel-Trenaunay syndrome complicated with intrahepatic cholestasis of pregnancy and disseminated intravascular coagulation.BMC pregnancy and childbirth · 2025Article
- Exploring Maralixibat for Treatment-Resistant Pruritus in Intrahepatic Cholestasis of Pregnancy and Primary Biliary Cholangitis: A Case Report.The American journal of case reports · 2025Article
- Intrahepatic Cholestasis of Pregnancy: Neonatal Impact Through the Lens of Current Evidence.Biomedicines · 2025Review
- Management of Recurrent Intrahepatic Cholestasis of Pregnancy: A Case Report.Journal of reproduction & infertility · 2025Article
- Association between ABCB4 variants and intrahepatic cholestasis of pregnancy.Scientific reports · 2025Article
- Novel estrogen-related gene variants identified by whole-exome sequencing in pregnancy-associated intrahepatic cholestasis.Frontiers in genetics · 2025Article
- Yinchenhao Decoction Protects Against Intrahepatic Cholestasis During Pregnancy Through the miR-370-3p/TM9SF4/KIT Axis.BioMed research international · 2025Article
- Pregnancy cholestasis typically occurs in the third trimester of pregnancy and is a significant clinical condition.Archives of gynecology and obstetrics · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease. The maternal symptoms are characterized by skin pruritus and elevated bile acids, causing several adverse outcomes for fetuses, including an increased risk of preterm birth, meconium-stained amniotic fluid, neonatal depression, respiratory distress syndrome, and stillbirth. Genetic, hormonal, immunological, and environmental factors contribute to the pathogenesis of ICP, and the estrogen-bile acid axis is thought to play a dominant role. The advances in the past 10 years uncover more details of this axis. Moreover, dysregulation of extracellular matrix and oxygen supply, organelle dysfunction, and epigenetic changes are also found to cause ICP, illuminating more potential drug targets for interfering with. Here, we summarize the molecular pathogenesis of ICP with an emphasis on the advancement in the past 10 years, aiming to give an updated full view of this field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.