ArticleJournal of traditional and complementary medicine2021
Therapeutic effects of eugenol in a rat model of traumatic brain injury: A behavioral, biochemical, and histological study.
Article in Journal of traditional and complementary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Eugenol mitigates schizophrenia-like behavioral deficits, oxidative stress, apoptosis, neuroinflammation, and cholinergic dysfunction in ketamine-induced mice.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Article
- Eugenol attenuates paclitaxel-induced cardiotoxicity by modulating autophagy-related markers in rats.Iranian journal of basic medical sciences · 2026Article
- Neuroprotective mechanism of syringic acid targeting oxidative damage and neuroinflammation in an experimental model of traumatic brain injury.Inflammopharmacology · 2026Article
- Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects.Food science & nutrition · 2025Review
- Eugenol attenuates aluminium-induced neurotoxicity in rats by inhibiting the activation of STAT3 and NF-кB.Metabolic brain disease · 2025Article
- Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits.IBRO neuroscience reports · 2024Article
- Weight-Drop Method for Inducing Closed Head Diffuse Traumatic Brain Injury.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Eugenol alleviates neuronal damage via inhibiting inflammatory process against pilocarpine-induced status epilepticus.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Review
- Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) fromEvidence-based complementary and alternative medicine : eCAM · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimTraumatic brain injury (TBI) results in death or long term functional disabilities. Eugenol is demonstrated to be beneficial in a range of experimental models of neurological disorders via its anti-inflammatory and antioxidant properties. Thus, the present study was designed to investigate the neuroprotective effects of eugenol in a weight-drop induced rat model of TBI. EXPERIMENTAL PROCEDURE: Rats were assigned into five groups; control and TBI groups pretreated with vehicle, and three TBI groups pretreated with different doses of eugenol (25, 50, and 100 mg/kg/day,
resultsWeight-drop induced TBI caused functional disabilities in the rats as indicated by impairment in locomotor activities and short term memory. The TBI also resulted in augmented neuronal cell death designated by chromatolysis. The results also showed disruption in the BBB integrity, increased edema, and lipid peroxidation in the brain of the rats exposed to trauma. Pretreatment with eugenol (100 mg/kg) ameliorated histopathological, neurochemical, and behavioral consequences of trauma.
conclusionFor the first time this study revealed that eugenol can be considered as a potential candidate for managing the functional disabilities associated with TBI because of its antioxidant activities.
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