Evidence map›Paper›PMID 34194969›Full record

ArticleLeukemia research reports2021

Potent efficacy of chlorpromazine in acute myeloid leukemia harboring

Shinya Rai, Hirokazu Tanaka, J Luis Espinoza, Takahiro Kumode, Itaru Matsumura

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shinya RaiDepartment of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-sayama, Osaka.
Hirokazu TanakaDepartment of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-sayama, Osaka.
J Luis EspinozaDepartment of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-sayama, Osaka.
Takahiro KumodeDepartment of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-sayama, Osaka.
Itaru MatsumuraDepartment of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-sayama, Osaka.
Kindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a heterogeneous disease often associated with poor prognosis. We previously showed that the localization of KIT-D816V at endolysosomes is critical to activate aberrant Akt signaling and Chlorpromazine (CPZ) perturbs the intracellular localization, leading to cell death in AML cells with

Indexed as

Acute myeloid leukemiaChlorpromazineIntracellular traffickingKit-d816vReceptor tyrosine kinase

Identifiers

PMID34194969
PMCPMC8233227
OpenAlexW3170398766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.