Evidence map›Paper›PMID 34194950›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.

James D Byrne, Cameron C Young, Jacqueline N Chu, Jennifer Pursley, Mu Xian Chen, Adam J Wentworth, Annie Feng, Ameya R Kirtane, Kyla A Remillard, Cindy I Hancox and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

James D ByrneDivision of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA.
Cameron C YoungDivision of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA.
Jacqueline N ChuDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.ORCID 0000-0003-1290-1634
Jennifer PursleyDivision of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA.
Mu Xian ChenDivision of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA.
Adam J WentworthDivision of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA.
Annie FengDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Ameya R KirtaneDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Kyla A RemillardDivision of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA.
Cindy I HancoxDepartment of Radiation Oncology Dana-Farber Cancer Institute/Brigham and Women's Hospital 44 Binney St. Boston MA 02115 USA.
Mandar S BhagwatDivision of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA.
Nicole MachadoDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Tiffany HuaDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Siddartha M TamangDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Joy E CollinsDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Keiko IshidaDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Alison HaywardDavid H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA.
Sarah L BeckerDivision of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA.
Samantha K EdgingtonDivision of Medical Physics Department of Radiation Oncology Massachusetts General Hospital 450 Brookline Avenue Boston MA 02115 USA.
Jonathan D SchoenfeldDepartment of Radiation Oncology Dana-Farber Cancer Institute/Brigham and Women's Hospital 44 Binney St. Boston MA 02115 USA.
William R JeckDepartment of Pathology Duke University Durham NC 27710 USA.
Chin HurDepartment of Medicine Columbia University Medical Center 622 West 168th Street, PH 9-105 New York NY 10032 USA.
Giovanni TraversoDivision of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA.ORCID 0000-0001-7851-4077
Brigham and Women's Hospital · USMassachusetts Institute of Technology · USMassachusetts General Hospital · USColumbia University Irving Medical Center · USDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D-printed GI radioprotective devices composed of high-Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (

Indexed as

Printing, Three-DimensionalAnimalsDisease Models, AnimalGastrointestinal TractHumansMouth NeoplasmsMucous MembraneOrgans at RiskRadiation InjuriesRadiation ProtectionRatsRats, Sprague-DawleySwineTomography, X-Ray Computed3D printingdosimetric analysisradiation attenuationradiation‐induced mucositisradiation proctitisradioprotective devices

Identifiers

PMID34194950
PMCPMC8224439
OpenAlexW3158939664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.