Evidence map›Paper›PMID 34194438›Full record

ArticleFrontiers in immunology2021

Potent SARS-CoV-2-Specific T Cell Immunity and Low Anaphylatoxin Levels Correlate With Mild Disease Progression in COVID-19 Patients.

Eliott Lafon, Gabriel Diem, Christina Witting, Viktoria Zaderer, Rosa Maria Bellmann-Weiler, Markus Reindl, Angelika Bauer, Andrea Griesmacher, Vilmos Fux, Gregor Hoermann and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Vaginal Clinical Isolates ofJournal of fungi (Basel, Switzerland) · 2025
    Article
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  7. SARS-CoV-2 immunity in animal models.Cellular & molecular immunology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Eliott LafonInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Gabriel DiemInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Christina WittingInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Viktoria ZadererInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Rosa Maria Bellmann-WeilerUniversity Hospital of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
Markus ReindlClinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Angelika BauerClinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Andrea GriesmacherCentral Institute for Medical and Chemical Laboratory Diagnosis, University Hospital Innsbruck, Innsbruck, Austria.
Vilmos FuxCentral Institute for Medical and Chemical Laboratory Diagnosis, University Hospital Innsbruck, Innsbruck, Austria.
Gregor HoermannCentral Institute for Medical and Chemical Laboratory Diagnosis, University Hospital Innsbruck, Innsbruck, Austria.
Carl MillerDepartment of Internal Medicine, Hospital Kufstein, Kufstein, Austria.
August ZaberniggDepartment of Internal Medicine, Hospital Kufstein, Kufstein, Austria.
Ewald WöllDepartment of Internal Medicine, Hospital Zams, Zams, Austria.
Doris WilflingsederInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Cornelia Lass-FlörlInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Wilfried PoschInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Universität Innsbruck · ATInnsbruck Medical University · ATUniversity Hospital Innsbruck · ATUniversity of Applied Sciences Kufstein · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cells play a fundamental role in the early control and clearance of many viral infections of the respiratory system. In SARS-CoV-2-infected individuals, lymphopenia with drastically reduced CD4

Indexed as

AdultAgedAged, 80 and overAnaphylatoxinsAntibodies, ViralCD8-Positive T-LymphocytesCOVID-19Disease ProgressionEnzyme-Linked Immunospot AssayFemaleFlow CytometryHumansImmunity, HumoralInterferon-gammaMaleMiddle AgedAnaphylatoxinsAntibodies, ViralInterferon-gammaanaphylatoxinCOVID-19ELISpot assayneutralizing AbsSARS-CoV-2T cell immunity

Identifiers

PMID34194438
PMCPMC8237940
OpenAlexW3166555921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.