Evidence map›Paper›PMID 34194421›Full record

ArticleFrontiers in immunology2021

Structural Comparison Between MHC Classes I and II; in Evolution, a Class-II-Like Molecule Probably Came First.

Yanan Wu, Nianzhi Zhang, Keiichiro Hashimoto, Chun Xia, Johannes M Dijkstra

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Sex Steroid Hormone Regulation of T-Cell Function and Antitumor Immunity.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
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  6. Brain communications · 2025
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  11. Review
  12. Antibody Cross-Reactivity in Auto-Immune Diseases.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Antigen Presentation and Autophagy in Teleost Adaptive Immunity.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yanan WuDepartment of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Nianzhi ZhangDepartment of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Keiichiro HashimotoInstitute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.
Chun XiaDepartment of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, China.
Johannes M DijkstraInstitute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structures of peptide-loaded major histocompatibility complex class I (pMHC-I) and class II (pMHC-II) complexes are similar. However, whereas pMHC-II complexes include similar-sized IIα and IIβ chains, pMHC-I complexes include a heavy chain (HC) and a single domain molecule β

Indexed as

Amino Acid SequenceAnimalsAntigensComputational BiologyEvolution, MolecularHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHLA AntigensHumansModels, ImmunologicalPeptidesProtein BindingProtein ConformationAntigensHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHLA AntigensPeptidesb2-microglobulinclass Iclass IIevolutionMHCpeptidestructure

Identifiers

PMID34194421
PMCPMC8236899

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.