ArticleFrontiers in endocrinology2021
Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06134258 (Mechanisms of Fasting Induced Reduction in Energy Expenditure - FIRE Trial), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms of Fasting Induced Reduction in Energy Expenditure - FIRE Trial
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Temperature as a Metabolic Signal Linking Neural and Endocrine Circuits to Energy Homeostasis.International journal of molecular sciences · 2026Review
- Review
- The effect of ambient temperature on thyroid function parameters: a daily level panel study.BMC public health · 2025Article
- Serum parameters and energy balance during the Yukon Arctic Ultra: a multistage ultramarathon in Arctic conditions.Frontiers in nutrition · 2025Article
- Temperature Differences Between Controlled Primary Hypothyroidism and Healthy Patients: An Exploratory Study.Journal of the Endocrine Society · 2024Article
- Brown Adipose Tissue-A Translational Perspective.Endocrine reviews · 2023Review
- The Role of Thyroid Hormones on Skeletal Muscle Thermogenesis.Metabolites · 2022Review
- Obesity and Thyroid Axis.International journal of environmental research and public health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone (TH) is an important regulator of mammalian metabolism and facilitates cold induced thermogenesis (CIT) in brown adipose tissue (BAT). Profound hypothyroidism or hyperthyroidism lead to alterations in BAT function and CIT. In euthyroid humans the inter-individual variation of thyroid hormones is relatively large. Therefore, we investigated whether levels of free thyroxine (T4) or free triiodothyronine (T3) are positively associated with CIT in euthyroid individuals. We performed an observational study in 79 healthy, euthyroid volunteers (mean age 25.6 years, mean BMI 23.0 kg · m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.