Evidence map›Paper›PMID 34194383›Full record

ArticleFrontiers in neurology2021

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis.

Yuting Ren, Siyuan Li, Siyu Chen, Xiaosun Sun, Fei Yang, Hongfen Wang, Mao Li, Fang Cui, Xusheng Huang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  4. TDP-43: [GU]-ardian of the transcriptome.Molecular neurodegeneration · 2026
    Review
  5. Review
  6. Review
  7. Reframing TDP-43 in Alzheimer's disease: From co-pathology to neurovascular culprit.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  8. Article
  9. Loss of Nuclear TDP-43 Impairs Lipid Metabolism in Microglia-Like Cells.bioRxiv : the preprint server for biology · 2025
    Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yuting RenDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Siyuan LiDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Siyu ChenDepartment of Geriatric Neurology, Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Xiaosun SunDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Fei YangDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Hongfen WangDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Mao LiDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Fang CuiDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Xusheng HuangDepartment of Neurology, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Chinese PLA General Hospital · CNTianjin Third Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

amyotrophic lateral sclerosisbiomarkerCSFplasmapTDP-43TDP-43

Identifiers

PMID34194383
PMCPMC8236522
OpenAlexW3172034907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.