Evidence map›Paper›PMID 34194329›Full record

ArticleFrontiers in pharmacology2021

Loganin Inhibits Angiotensin II-Induced Cardiac Hypertrophy Through the JAK2/STAT3 and NF-κB Signaling Pathways.

Jia-Jia Xu, Run-Jing Li, Zheng-Hao Zhang, Cui Yang, Shi-Xiao Liu, Yan-Ling Li, Min-Wei Chen, Wei-Wei Wang, Gong-Ye Zhang, Gang Song and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Journal of pharmacopuncture · 2026
    Review
  2. Loganin Alleviates CClChinese journal of integrative medicine · 2026
    Article
  3. Article
  4. Signaling Pathways and Therapeutic Approaches in Post-Myocardial Infarction Fibrosis.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. mFrontiers of medicine · 2024
    Article
  17. [mRNA Expression Profile Changes in Angiotensin-Ⅱ-Induced Atrial Myocardial Fibrosis in Rats].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jia-Jia XuDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Run-Jing LiDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Zheng-Hao ZhangDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Cui YangDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Shi-Xiao LiuDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Yan-Ling LiDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Min-Wei ChenDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Wei-Wei WangCancer Research Center, School of Medicine, Xiamen University, Xiamen, China.
Gong-Ye ZhangCancer Research Center, School of Medicine, Xiamen University, Xiamen, China.
Gang SongCancer Research Center, School of Medicine, Xiamen University, Xiamen, China.
Zheng-Rong HuangDepartment of Cardiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
First Affiliated Hospital of Xiamen University · CNXiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loganin is an iridoid glycoside extracted from

Indexed as

angiotensin IIcardiac fibrosiscardiac hypertrophyinflammationJAK2/STAT3loganinNF-kB

Identifiers

PMID34194329
PMCPMC8237232
OpenAlexW3167142801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.