Evidence map›Paper›PMID 34194314›Full record

ArticleFrontiers in aging neuroscience2021

Mind-Body Exercise Modulates Locus Coeruleus and Ventral Tegmental Area Functional Connectivity in Individuals With Mild Cognitive Impairment.

Jiao Liu, Jing Tao, Rui Xia, Moyi Li, Maomao Huang, Shuzhen Li, Xiangli Chen, Georgia Wilson, Joe Park, Guohua Zheng and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 15 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 15 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Jiao LiuCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Jing TaoCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Rui XiaCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Moyi LiCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Maomao HuangCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Shuzhen LiCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Xiangli ChenDepartment of Rehabilitation Psychology and Special Education, University of Wisconsin, Madison, WI, United States.
Georgia WilsonDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Joe ParkDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Guohua ZhengSchool of Nursing and Health Management, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Lidian ChenCollege of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Jian KongDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Fujian University of Traditional Chinese Medicine · CNHarvard University · USMassachusetts General Hospital · USShanghai University of Medicine and Health Sciences · CNUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mild cognitive impairment (MCI) is a common global health problem. Recently, the potential of mind-body intervention for MCI has drawn the interest of investigators. This study aims to comparatively explore the modulation effect of Baduanjin, a popular mind-body exercise, and physical exercise on the cognitive function, as well as the norepinephrine and dopamine systems using the resting state functional connectivity (rsFC) method in patients with MCI. 69 patients were randomized to the Baduanjin, brisk walking, or healthy education control group for 6 months. The Montreal Cognitive Assessment (MoCA) and magnetic resonance imaging (MRI) scans were applied at baseline and at the end of the experiment. Results showed that (1) compared to the brisk walking, the Baduanjin significantly increased MoCA scores; (2) Baduanjin significantly increased the right locus coeruleus (LC) and left ventral tegmental area (VTA) rsFC with the right insula and right amygdala compared to that of the control group; and the right anterior cingulate cortex (ACC) compared to that of the brisk walking group; (3) the increased right LC-right insula rsFC and right LC-right ACC rsFC were significantly associated with the corresponding MoCA score after 6-months of intervention; (4) both exercise groups experienced an increased effective connectivity from the right ACC to the left VTA compared to the control group; and (5) Baduanjin group experienced an increase in gray matter volume in the right ACC compared to the control group. Our results suggest that Baduanjin can significantly modulate intrinsic functional connectivity and the influence of the norepinephrine (LC) and dopamine (VTA) systems. These findings may shed light on the mechanisms of mind-body intervention and aid the development of new treatments for MCI.

Indexed as

Baduanjinlocus coeruleusmild cognitive impairmentresting state functional connectivityventral tegmental area

Identifiers

PMID34194314
PMCPMC8236862
OpenAlexW3171245392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.