Evidence map›Paper›PMID 34194228›Full record

ArticleInternational journal of nanomedicine2021

α-Helical Antimicrobial Peptide Encapsulation and Release from Boron Nitride Nanotubes: A Computational Study.

Maryam Zarghami Dehaghani, Farrokh Yousefi, Babak Bagheri, Farzad Seidi, Amin Hamed Mashhadzadeh, Navid Rabiee, Payam Zarrintaj, Ebrahim Mostafavi, Mohammad Reza Saeb, Yeu-Chun Kim

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Article in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maryam Zarghami DehaghaniJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, People's Republic of China.
Farrokh YousefiDepartment of Physics, University of Zanjan, Zanjan, 45195-313, Iran.ORCID 0000-0001-7427-5363
Babak BagheriDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.ORCID 0000-0001-6137-6376
Farzad SeidiJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, People's Republic of China.
Amin Hamed MashhadzadehCenter of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.ORCID 0000-0001-8146-8198
Navid RabieeDepartment of Chemistry, Sharif University of Technology, Tehran, 11155-3516, Iran.ORCID 0000-0002-6945-8541
Payam ZarrintajSchool of Chemical Engineering, Oklahoma State University, Stillwater, OK, 74078, USA.
Ebrahim MostafaviStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3958-5002
Mohammad Reza SaebCenter of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Yeu-Chun KimDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAntimicrobial peptides are potential therapeutics as anti-bacteria, anti-viruses, anti-fungi, or anticancers. However, they suffer from a short half-life and drug resistance which limit their long-term clinical usage.

methodsHerein, we captured the encapsulation of antimicrobial peptide HA-FD-13 into boron nitride nanotube (BNNT) (20,20) and its release due to subsequent insertion of BNNT (14,14) with molecular dynamics simulation.

resultsThe peptide-BNNT (20,20) van der Waals (vdW) interaction energy decreased to -270 kcal·mol DISCUSSION: Once the BNNT (14,14) entered into the BNNT (20,20), the peptide was completely released after 83.8 ps. This revealed that the vdW interaction between the BNNT (14,14) and BNNT (20,20) was stronger than between BNNT (20,20) and the peptide; therefore, the BNNT (14,14) could act as a piston pushing the peptide outside the BNNT (20,20). Moreover, the sudden drop in the vdW energy between nanotubes to the value of the -1300 Kcal·mol

Indexed as

Boron CompoundsMolecular Dynamics SimulationNanotubesPore Forming Cytotoxic ProteinsProtein Conformation, alpha-HelicalBoron Compoundsboron nitridePore Forming Cytotoxic Proteinsantimicrobial peptideboron nitride nanotubesdrug deliverydrug releasemolecular dynamics simulation

Identifiers

PMID34194228
PMCPMC8238539

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.