ReviewNeuro-ophthalmology (Aeolus Press)2021
Radiation-Induced Optic Neuropathy: Literature Review.
Review in Neuro-ophthalmology (Aeolus Press), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Multimodal Characterization of Radiation-Induced Optic Neuropathy after Proton Radiotherapy.Ophthalmology science · 2026Article
- Ophthalmic complications of radiotherapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- Article
- Microvascular Abnormalities, Inner Retina Thinning and Sectorial Optic Atrophy after Low-dose Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: A Case Report.Klinische Monatsblatter fur Augenheilkunde · 2025Article
- Taxane-associated retinopathy and radiation-induced optic neuropathy in a young female patient with metastatic breast cancer.GMS ophthalmology cases · 2025Article
- Possible association of dose rate and the development of late visual toxicity for patients with intracranial tumours treated with pencil beam scanned proton therapy.Radiation oncology (London, England) · 2024Article
- Stereotactic radiotherapy for uveal melanoma: A case report.Molecular and clinical oncology · 2024Article
- Neurologic Complications in Adult Cancer Survivorship.Seminars in neurology · 2024Article
- Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?Radiation oncology (London, England) · 2023Article
- Outcomes of systemic bevacizumab in radiation-induced optic neuropathy, case series.Journal of neuro-oncology · 2023Article
- Definitive-intent (chemo)radiotherapy for sinonasal undifferentiated carcinoma.The British journal of radiology · 2023Article
- Bilateral Blindness Due to Radiation-Induced Optic Neuropathy in a Patient with Nasal Mucosal Melanoma.Romanian journal of ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiation-induced optic neuropathy (RION) is a rare disease caused by exposure of the optic nerves to radiation during radiotherapy procedures for head and neck tumours. The purpose of this study was to review and summarise the epidemiology, risk factors, clinical presentations, pathphysiology characteristics, diagnosis, and management of RION. Its occurrence is associated with cumulative doses of radiation above 50 Gy, presence of multi-morbidities and the presence of concomitant chemotherapy and radiotherapy. It manifests with acute, painless, and monocular loss of vision, and these symptoms appear late after the radiation exposure. The diagnosis of the disease occurs by exclusion and, mainly, by the clinical analysis of the case associated with the time of radiation exposure. Treatment does not seem promising and there is not an effective cure. In this review, we mainly focus on compiling existing information on the topic and providing knowledge for early diagnosis and more efficient treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.