ArticleNature2021
Shape of promoter antisense RNAs regulates ligand-induced transcription activation.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Decoding chromatin-associated RNA (caRNA) interaction networks: from genome-wide dynamic capture to epigenetic mechanisms in plants and animals.Epigenetics · 2026Review
- H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers.Nature communications · 2026Article
- Progress and challenges in profiling protein-RNA and protein-associated RNA-RNA interactions.RNA (New York, N.Y.) · 2026Review
- Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation.Science (New York, N.Y.) · 2026Article
- Widespread impact of nucleosome remodelers on transcription at cis-regulatory elements.Cell reports · 2025Article
- Rewired m6A of promoter antisense RNAs in Alzheimer's disease regulates neuronal genes in 3D nucleome.Nature communications · 2025Article
- An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs.Nature genetics · 2025Article
- Long non-coding RNAs in response to Ebola virus vaccine-induced immunity.Frontiers in immunology · 2025Article
- KAP1 in antiviral immunity: dual roles in viral silencing and immune regulation.Frontiers in cellular and infection microbiology · 2025Review
- KAP1/TRIM28 - antiviral and proviral protagonist of herpesvirus biology.Trends in microbiology · 2024Article
- An RNA-centric view of transcription and genome organization.Molecular cell · 2024Review
- Identification of RNA structures and their roles in RNA functions.Nature reviews. Molecular cell biology · 2024Review
- Role of long noncoding RNAs in diabetes-associated peripheral arterial disease.Cardiovascular diabetology · 2024Review
- Transcription factors ERα and Sox2 have differing multiphasic DNA- and RNA-binding mechanisms.RNA (New York, N.Y.) · 2024Article
- RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5.Genome biology · 2024Article
- Transcription factors ERα and Sox2 have differing multiphasic DNA and RNA binding mechanisms.bioRxiv : the preprint server for biology · 2024Article
- Review
- PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs.Nature communications · 2023Article
- Regulation of the epigenome through RNA modifications.Chromosoma · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Fan Yang *Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA. fay009@health.ucsd.edu.ORCID http://orcid.org/0000-0003-4440-6128
Bogdan Tanasa *Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.
Rudi MichelettiHoward Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Kenneth A OhgiHoward Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Aneel K AggarwalDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4389-0173
Michael G RosenfeldHoward Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA. mrosenfeld@health.ucsd.edu.ORCID http://orcid.org/0000-0002-1572-156X
Howard Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · USStanford University · US
Funding
HORMONAL AND DEVELOPMENTAL REGULATION OF GENE EXPRESSIONR01DK018477 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1986 to 2025
$12.7MREGULATION OF NEUROENDOCRINE SWITCHING EVENTSR37DK039949 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1987 to 2020
$12.3MStanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0MStructure and Specificity of Restriction-Modification (R-M) SystemsR35GM131780 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANEEL K. AGGARWAL · 2019 to 2026
$3.4MA stress-induced promoter pause release program in cardiomyocytes protecting against myocardial infarctionR01HL150521 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2020 to 2023
$2.7MREGULATION OF NEUROENDOCRINE SWITCHING EVENTSR01DK039949 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 1996 to 2024
$2.4MChromosomal Boundary Alterations Driving Transcriptional Dysregulation in Brain DisordersR01NS093066 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2016 to 2020
$2.4MHoward Hughes Medical InstituteNEI NIH HHS P30 EY026877NHLBI NIH HHS R01 HL150521NIDDK NIH HHS R01 DK018477NIDDK NIH HHS R01 DK039949NIDDK NIH HHS R37 DK039949NIGMS NIH HHS R35 GM131780NINDS NIH HHS R01 NS093066
Abstract
The size of the transcriptional program of long non-coding RNAs in the mammalian genome has engendered discussions about their biological roles
Indexed as
Nucleic Acid ConformationCell LineChromobox Protein Homolog 5Crk-Associated Substrate ProteinEstrogen Receptor alphaHistonesHumansJumonji Domain-Containing Histone DemethylasesLigandsPositive Transcriptional Elongation Factor BPromoter Regions, GeneticRNA, AntisenseRNA Polymerase IIRNA StabilityTranscriptional ActivationTripartite Motif-Containing Protein 28Bcar1 protein, mouseChromobox Protein Homolog 5Crk-Associated Substrate ProteinEstrogen Receptor alphaHistonesHP1-alpha protein, humanJumonji Domain-Containing Histone DemethylasesKDM4B protein, humanKDM4C protein, humanLigandsPositive Transcriptional Elongation Factor BRNA, AntisenseRNA Polymerase IITRIM28 protein, humanTripartite Motif-Containing Protein 28
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.