Evidence map›Paper›PMID 34194012›Full record

ReviewNature reviews. Drug discovery2021

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.

Henry Jay Forman, Hongqiao Zhang

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Drug discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1,332 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,332citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,332 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Effect of anNutrients · 2026
    Trial
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  7. Therapeutic potential ofPharmaceutical biology · 2026
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  8. A bilayer hydrogel with a lower layer ROS-responsive Au-CeOInternational journal of pharmaceutics: X · 2026
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1,272 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Henry Jay FormanUniversity of California Merced, Merced, CA, USA. peroxideman@gmail.com.ORCID http://orcid.org/0000-0001-5838-2791
Hongqiao ZhangLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Funding

Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, FINCH, CALEB E · 2018 to 2022
$11.5M
NIA NIH HHS P01 AG055367
6 · The paper itself

Abstract

Oxidative stress is a component of many diseases, including atherosclerosis, chronic obstructive pulmonary disease, Alzheimer disease and cancer. Although numerous small molecules evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, clinical trial results have been disappointing. A greater understanding of the mechanisms through which antioxidants act and where and when they are effective may provide a rational approach that leads to greater pharmacological success. Here, we review the relationships between oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can contribute to pathology, how antioxidant defences work, what limits their effectiveness and how antioxidant defences can be increased through physiological signalling, dietary components and potential pharmaceutical intervention.

Indexed as

Drug DevelopmentAnimalsAntioxidantsDrug Evaluation, PreclinicalHumansMolecular Targeted TherapyOxidation-ReductionOxidative StressSignal TransductionAntioxidants

Identifiers

PMID34194012
PMCPMC8243062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.