ArticleHorticulture research2021
The R2R3-type MYB transcription factor MdMYB90-like is responsible for the enhanced skin color of an apple bud sport mutant.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 63 citations in OpenAlex.
- Multifaceted mechanisms underlying species- and cultivar-associated differential anthocyanin accumulation in fruits.Horticulture research · 2026Article
- Article
- Hydrogen sulfide-mediated persulfidation of ERF106 controls pear fruit aroma biosynthesis via disrupting the ERF106-MYB21-FAD8 complex.The Plant journal : for cell and molecular biology · 2026Article
- The FaDOF2-FaMYB4 transcriptional module regulates anthocyanin biosynthesis in strawberry fruit.Plant cell reports · 2026Article
- Integration of ATAC-seq and RNA-seq profiling reveals an epigenetic regulator of anthocyanin synthesis in Prunus mume.BMC plant biology · 2026Article
- Unraveling GhMYB102: dual roles of Gh_A01G069800 in inhibiting anthocyanin biosynthesis and inducing drought tolerance in cotton.BMC genomics · 2026Article
- Review
- Combined analysis of lncRNAs and mRNAs associated with coloration and wax formation during 'Fumei' Apple development.BMC plant biology · 2025Article
- A chromosome-levelActa pharmaceutica Sinica. B · 2025Article
- Increased genomic predictive ability in mango using GWAS-preselected variants and fixed-effect SNPs.Frontiers in plant science · 2025Article
- Hypermethylation in the promoter regions of flavonoid pathway genes is associated with skin color fading during 'Daihong' apple fruit development.Horticulture research · 2024Article
- Article
- Metabolomic and transcriptomic analyses provide insights into variations in flavonoids contents between two Artemisia cultivars.BMC plant biology · 2023Article
- Genome-Wide Identification and Analysis ofInternational journal of molecular sciences · 2023Article
- Somatic Mutations in Fruit Trees: Causes, Detection Methods, and Molecular Mechanisms.Plants (Basel, Switzerland) · 2023Review
- Insights on the stem elongation of spur-type bud sport mutant of 'Red Delicious' apple.Planta · 2023Article
- Characterization of Highbush Blueberry (Current issues in molecular biology · 2023Article
- Article
- Anthocyanin Accumulation and Molecular Analysis of Correlated Genes by Metabolomics and Transcriptomics in Sister Line Apple Cultivars.Life (Basel, Switzerland) · 2022Article
- Apple Fruit Growth and Quality Depend on the Position in Tree Canopy.Plants (Basel, Switzerland) · 2022Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The anthocyanin content in apple skin determines its red coloration, as seen in a Fuji apple mutant. Comparative RNA-seq analysis was performed to determine differentially expressed genes at different fruit development stages between the wild-type and the skin color mutant. A novel R2R3-MYB transcription factor, MdMYB90-like, was uncovered as the key regulatory gene for enhanced coloration in the mutant. The expression of MdMYB90-like was 21.3 times higher in the mutant. MdMYB90-like regulates anthocyanin biosynthesis directly through the activation of anthocyanin biosynthesis genes and indirectly through the activation of other transcription factors that activate anthocyanin biosynthesis. MdMYB90-like bound to the promoters of both structural genes (MdCHS and MdUFGT) and other transcription factor genes (MdMYB1 and MdbHLH3) in the yeast one-hybrid system, electrophoretic mobility shift assay, and dual-luciferase assay. Transgenic analysis showed that MdMYB90-like was localized in the nucleus, and its overexpression induced the expression of other anthocyanin-related genes, including MdCHS, MdCHI, MdANS, MdUFGT, MdbHLH3, and MdMYB1. The mutant had reduced levels of DNA methylation in two regions (-1183 to -988 and -2018 to -1778) of the MdMYB90-like gene promoter, which might explain the enhanced expression of the gene and the increased anthocyanin content in the mutant apple skin.
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Registered trials
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