Evidence map›Paper›PMID 34193641›Full record

ArticleThe Korean journal of pain2021

The role of percutaneous neurolysis in lumbar disc herniation: systematic review and meta-analysis.

Laxmaiah Manchikanti, Emilija Knezevic, Nebojsa Nick Knezevic, Mahendra R Sanapati, Alan D Kaye, Srinivasa Thota, Joshua A Hirsch

Open access · diamondAbstract read
In one paragraph

Article in The Korean journal of pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Minimal-invasive pain procedures are effective in different degenerative pain generators in CLBP: A prospective cohort study.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Laxmaiah ManchikantiPain Management Centers of America, Paducah, KY & Evansville, IN, USA.ORCID https://orcid.org/0000-0002-4201-9063
Emilija KnezevicUniversity of Illinois at Urbana-Champaign, College of Liberal Arts and Sciences, Champaign, IL, USA.ORCID https://orcid.org/0000-0002-7200-5295
Nebojsa Nick KnezevicAdvocate Illinois Masonic Medical Center and College of Medicine, University of Illinois, Chicago, IL, USA.ORCID https://orcid.org/0000-0001-8028-1495
Mahendra R SanapatiPain Management Centers of America, Paducah, KY & Evansville, IN, USA.ORCID https://orcid.org/0000-0002-1047-0765
Alan D KayeLSU Health Sciences Center, Shreveport, Ochsner Shreveport Hospital and Pain Clinic Feist-Wieller Cancer Center, Shreveport, LA, USA.ORCID https://orcid.org/0000-0003-2464-0187
Srinivasa ThotaPain Management Centers of America, Paducah, KY & Evansville, IN, USA.ORCID https://orcid.org/0000-0002-3946-6751
Joshua A HirschMassachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-9594-8798
Pain Management Centers Of America · USHarvard University · USLouisiana State University Health Sciences Center Shreveport · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecalcitrant disc herniation may result in chronic lumbar radiculopathy or sciatica. Fluoroscopically directed epidural injections and other conservative modalities may provide inadequate improvement in some patients. In these cases, percutaneous neurolysis with targeted delivery of medications is often the next step in pain management.

methodsAn evidence-based system of methodologic assessment, namely, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used. Multiple databases were searched from 1966 to January 2021. Principles of the best evidence synthesis were incorporated into qualitative evidence synthesis. The primary outcome measure was the proportion of patients with significant pain relief and functional improvement (≥ 50%). Duration of relief was categorized as short-term (< 6 months) and long-term (≥ 6 months).

resultsThis assessment identified one high-quality randomized controlled trial (RCT) and 5 moderate-quality non-randomized studies with an application of percutaneous neurolysis in disc herniation. Overall, the results were positive, with level II evidence.

conclusionsBased on the present systematic review, with one RCT and 5 nonrandomized studies, the evidence level is II for percutaneous neurolysis in managing lumbar disc herniation.

Indexed as

CatheterizationEpidural SpaceEvidence-Based MedicineHypertonicIntervertebral Disc DisplacementLow Back PainMeta-AnalysisObservational StudyPain ManagementRadiculopathyRandomized Controlled TrialSaline SolutionSystematic Review.

Identifiers

PMID34193641
PMCPMC8255147
OpenAlexW3176646790

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.