Evidence map›Paper›PMID 34193602›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients.

Rashmi Tippalagama, Akul Singhania, Paige Dubelko, Cecilia S Lindestam Arlehamn, Austin Crinklaw, Mikhail Pomaznoy, Gregory Seumois, Aruna D deSilva, Sunil Premawansa, Dhammika Vidanagama and 11 more

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
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  7. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Exhausted T cell phenotypes in disseminated coccidioidomycosis.medRxiv : the preprint server for health sciences · 2026
    Article
  12. Decidual CD4 Effector Memory and Resident Memory T Cells Respond to Cord Blood Allo-Antigens.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Article
  13. Metabolic adaptations rewire CD4Nature immunology · 2026
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 9 institutions in 7 countries.

Rashmi TippalagamaVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0001-6157-8592
Akul SinghaniaVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.
Paige DubelkoVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.
Cecilia S Lindestam ArlehamnVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0001-7302-8002
Austin CrinklawVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-3586-4533
Mikhail PomaznoyVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.
Gregory SeumoisVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.ORCID 0000-0002-8164-6852
Aruna D deSilvaVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.
Sunil PremawansaFaculty of Science, University of Colombo, Colombo, Sri Lanka.
Dhammika VidanagamaNational Tuberculosis Reference Laboratory, Welisara, Sri Lanka.
Bandu GunasenaNational Hospital for Respiratory Diseases, Welisara, Sri Lanka.
N D Suraj GoonawardhanaFaculty of Medicine, General Sir John Kotelawala Defense University, Ratmalana, Sri Lanka.ORCID 0000-0002-3244-4402
Dinuka AriyaratneFaculty of Medicine, General Sir John Kotelawala Defense University, Ratmalana, Sri Lanka.ORCID 0000-0002-9843-5795
Thomas J ScribaSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0641-1359
Robert H GilmanJohns Hopkins School of Public Health, Baltimore, MD.ORCID 0000-0002-9037-0712
Mayuko SaitoDepartment of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID 0000-0003-4622-7027
Randy TaplitzDepartment of Medicine, City of Hope National Medical Center, Duarte, CA; and.
Pandurangan VijayanandVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.
Alessandro SetteVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA.
Bjoern PetersVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA; jburel@lji.org bpeters@lji.org.ORCID 0000-0002-8457-6693
Julie G BurelVaccine Discovery Division, La Jolla Institute for Immunology, La Jolla, CA; jburel@lji.org bpeters@lji.org.ORCID 0000-0003-1692-2758
La Jolla Institute for Immunology · USGeneral Sir John Kotelawala Defence University · LKCity Of Hope National Medical Center · USJohns Hopkins University · USNational Tuberculosis Institute · INTohoku University · JPUniversity of Cape Town · ZAUniversity of Colombo · LKWelsh National College · GB

Funding

Single-cell atlas of lung tissue-resident memory T cells reactive to upper and lower respiratory tract pathogensU19AI118626 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Bjoern Peters · 2015 to 2026
$36.7M
NIAID NIH HHS U19 AI118626
6 · The paper itself

Abstract

Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector cells from other T cell populations. To address this, we investigated the molecular profile of T cells present in individuals with active tuberculosis (ATB), where we expect Ag encounter and expansion of effector cells to occur at higher frequency in contrast to

Indexed as

Mycobacterium tuberculosisTuberculosisCD4-Positive T-LymphocytesHLA-DR AntigensHumansHLA-DR Antigens

Identifiers

PMID34193602
PMCPMC8516689
OpenAlexW3173871122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.