Evidence map›Paper›PMID 34193553›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Corticotropin-Releasing Hormone from the Pontine Micturition Center Plays an Inhibitory Role in Micturition.

Jason P Van Batavia, Stephan Butler, Eleanor Lewis, Joanna Fesi, Douglas A Canning, Stefano Vicini, Rita J Valentino, Stephen A Zderic

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Spinal Circuit for Modular Gating of Organ Somatosensation.bioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Somatostatin Neurons in the Mouse Pontine Nucleus Activate GABAFrontiers in synaptic neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jason P Van BataviaDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 vanbatavij@chop.edu.ORCID https://orcid.org/0000-0002-1592-7824
Stephan ButlerDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Eleanor LewisDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Joanna FesiDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Douglas A CanningDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Stefano ViciniDepartment of Pharmacology and Physiology, Georgetown, University Medical Center, Washington, DC 20007.
Rita J ValentinoDepartment of Anesthesia and Critical Care, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Stephen A ZdericDivision of Urology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104.
Children's Hospital of Philadelphia · USGeorgetown University Medical Center · US

Funding

Institutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7M
Defining the role of CRH-expressing neurons in Barrington's Nucleus (BN) and Characterizing the other neuronal subpopulations in BNK08DK120934 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI VAN BATAVIA, JASON PHILIP · 2019 to 2022
$695k
NCATS NIH HHS KL2 TR001879NIDDK NIH HHS K08 DK120934NIDDK NIH HHS L40 DK122486
6 · The paper itself

Abstract

Lower urinary tract or voiding disorders are prevalent across all ages and affect >40% of adults over 40 years old, leading to decreased quality of life and high health care costs. The pontine micturition center (PMC; i.e., Barrington's nucleus) contains a large population of neurons that localize the stress-related neuropeptide, corticotropin-releasing hormone (CRH) and project to neurons in the spinal cord to regulate micturition. How the PMC and CRH-expressing neurons in the PMC control volitional micturition is of critical importance for human voiding disorders. To investigate the specific role of CRH in the PMC, neurons in the PMC-expressing CRH were optogenetically activated during

Indexed as

Afferent PathwaysAnimalsArchaeal ProteinsBarrington's NucleusChannelrhodopsinsCorticotropin-Releasing HormoneCyclophosphamideCystitisFemaleGenes, ReporterMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsOptogeneticsArchaeal Proteinsarchaerhodopsin protein, ArchaeaChannelrhodopsinsCorticotropin-Releasing HormoneCyclophosphamideProton PumpsRecombinant ProteinsBarrington's nucleuslower urinary tract symptomsmicturitionneuro-urologyoptogeneticspontine micturition center

Identifiers

PMID34193553
PMCPMC8387110
OpenAlexW3177117399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.