Evidence map›Paper›PMID 34193508›Full record

ArticleeNeuro

Chronic, Episodic Nicotine Alters Hypoglossal Motor Neuron Function at a Critical Developmental Time Point in Neonatal Rats.

Lila Buls Wollman, Ralph F Fregosi

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Developmental nicotine exposure alters cardiovascular structure and function in neonatal and juvenile rats.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lila Buls WollmanDepartment of Physiology, The University of Arizona, Tucson, AZ 85724.
Ralph F FregosiDepartment of Physiology, The University of Arizona, Tucson, AZ 85724 fregosi@arizona.edu.
University of Arizona · US

Funding

Chronic nicotine and synaptic transmission in brainstem respiratory neuronsR01HD071302 · NICHD · UNIVERSITY OF ARIZONA · PI FREGOSI, RALPH FRANK · 2012 to 2022
$3.5M
Functional and Structural Diversity in Hypoglossal MotoneuronsR01DC020889 · NIDCD · UNIVERSITY OF ARIZONA · PI Ralph Frank Fregosi · 2023 to 2026
$1.7M
NICHD NIH HHS R01 HD071302NIDCD NIH HHS R01 DC020889
6 · The paper itself

Abstract

Developmental nicotine exposure (DNE), alters brainstem neurons that control breathing, including hypoglossal motor neurons (XIIMNs), which innervate the tongue. Here, we tested the hypothesis that chronic, episodic DNE (eDNE), which mimics nicotine replacement therapies such as e-cigarettes or nicotine gum, alters the function of nicotinic acetylcholine receptors (nAChRs), XIIMN intrinsic properties, and tongue muscle function

Indexed as

Electronic Nicotine Delivery SystemsPrenatal Exposure Delayed EffectsReceptors, NicotinicSmoking CessationAnimalsAnimals, NewbornFemaleHypoglossal NerveMotor NeuronsNicotinePregnancyRatsRats, Sprague-DawleyTobacco Use Cessation DevicesNicotineReceptors, Nicotinicfiring ratehomeostatic plasticityneuron developmentneurotoxinpattern sensitivitypotassium conductance

Identifiers

PMID34193508
PMCPMC8366915
OpenAlexW3176657800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.